Contact Details
Dr Paul Loadman
Senior Lecturer in Pharmacokinetics and Drug Metabolism
P.M.Loadman@bradford.ac.uk
Tel/ext: +44 (0) 1274 233228
Fax: +44 (0) 1274 233234
Qualifications
PhD (Bradford), BSc Hons (CNAA)
Main research interests
- Pharmacokinetics and tumour drug metabolism of anti cancer drugs
- Matrix metalloproteinases as targets for tumour-selective delivery of anticancer therapeutics
- Drug delivery and prodrug design
- Novel advances in analytical techniques. HPLC, GC, CE and LC/MS/MS
- Drug interactions both in vitro and in vivo
Roles and Responsibilities
- Team Leader: DMPK
- Management of DMPK and Clinical Pharmacology Group
- Deputy Institute Safety Liaison Officer
- Institute local education authority Nuffield placement liaison
- Laboratory Coordinator of Phase I clinical trials
Key publications
- N. Isambert, M. Campone, E. Bourbouloux, M. Drouin, A. Major, W. Yin, P.M. Loadman, R. Capizzi, C. Grieshaber, P. Fumoleau, "Evaluation of the safety of C-1311 (SYMADEX) administered in a phase 1 dose escalation trial as a weekly infusion for 3 consecutive weeks in patients with advanced solid tumours" European Journal of Cancer, (2010), 46, 4, 729-734
- Gillian Hawcroft, Paul M. Loadman, Andrea Belluzzi, Mark A Hull, "The effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signalling in human colorectal cancer cells," Neoplasia, (2010);12(8):618-27
- Jennifer M Atkinson, Robert A Falconer, Dylan R Edwards, Caroline J Pennington, Catherine S Siller, Steven D Shnyder, Michael C Bibby, Laurence H Patterson, Paul M Loadman, Jason H Gill "Development of a tumor-targeted vascular disrupting agent activated by Membrane-type Matrix Metalloproteinases (MT-MMPs)," Cancer Research, (2010) 70:6902-6912
- Daniel Hochhauser, Timothy Meyer, Victoria J Spanswick, Jenny Wu, Peter H Clingen, Paul M. Loadman, Margaret Cobb, Lindsey Gumbrell, Richard H Begent, John A Hartley and Duncan Jodrell "Phase 1 Study Of A Sequence Selective Minor Groove DNA Binding Agent (SJG-136) With Pharmacokinetic And Pharmacodynamic Measurements In Patients With Advanced Solid Tumours," (2009), Clin Cancer Res 15(6): 2140-7
- Kaye J. Williams, Mark R. Albertella, Brian Fitzpatrick, Paul M. Loadman, Steven D. Shnyder, Edwin C. Chinje, Brian A. Telfer, Chris R. Dunk, Peter A. Harris and Ian J. Stratford, "In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenograft," (2009), Molecular Cancer Therapeutics, 8(12):3266–75
- Albertella M.R., Loadman P.M., Jones P.H., Phillips R.M., Rampling R., Burnet N., Alcock C., Anthoney A., Vjaters E., Dunk C.R., Harris P.A., Wong A., Lalani A.S. and Twelves C.J. "Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase 1 study." (2008), Clinical Cancer Research,14, 1096-1104
Research Team
- Amanda Race, Research Technician
- Jason Lyle, Research Assistant
Postgraduate student supervision
- Mohammed N.Al-andas (Joint supervision with Prof Laurence Patterson) PhD project: Cytochrome P450-activated prodrugs
- Ahmed M.M. Youssef (Joint supervision with Dr Rob Falconer and Dr Jason Gill) PhD project: MMP-activated peptide prodrugs
- John Hutchinson, University of Leeds (Joint supervision with Prof Mark Hull, University of Leeds and Prof Anna Nicolau, University of Bradford) PhD project: Defining the anti-colorectal cancer activity of Resolvin E1
- Hannah Bateson (Joint supervision with Dr Chris Sutton) PhD project: Development of new methods for purifying and characterising membrane proteins from cancer related samples
- Hafiz Makeen (Joinr supervision with Dr Roger Phillips) PhD project: Quantitative cancer therapeutics; from model to clinic. Funded by Yorkshire Cancer Research. Award expected 2011
Teaching responsibilities
- Lectures:MSc in Cancer Pharmacology
- Lectures: BSc. & MSc Final Year: Oncology and Toxicology Module
- Lectures: MSc Biomedical Science: Research & Analytical Methods
- Lectures: BSc Second Year module: Analytical Biochemistry
- Lectures: BSc.& MSc Final Year: Molecular Pharmacology
- Guest Lectures University of London
- Guest Lectures University of Leeds
- Guest Lectures University of Napier
Professional Society Memberships
- Member of the British Association for Cancer Research
- Member of the Institute of Biology
- Member of the American Association for Cancer Research
- Member of Pharmacokinetics and Molecular Mechanisms (PAMM) Group, EORTC