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Dr Krzysztof Paluch

PositionLecturer in Medicines Development and Pharmaceutical Science
LocationNorcroft building, room 3.16
DepartmentSchool of Pharmacy
RKT CentrePharmaceutical Engineering
Telephone+44 (0) 1274 236110
EmailK.J.Paluch@bradford.ac.uk
LinkedInVisit my LinkedIn profile

Research Interests (key words only)

Solid-state and micromeritic characterisation of spray dried mmaterials; Physicochemical characterisation of high-energy forms of active pharmaceutical ingredients; Nanoparticulate delivery systems; Co-crystalline complexes screening and characterisation; Dissolution, Solubility, Permeability

PhD Supervision

Hanan Abdalmaula MPharm., M.Sc.- "Pre- and post-processing physicochemical and micromeritic characterisation of active pharmaceutical ingredients"

Fatima Aloum MPharm.- "Novel fundamental approaches to selection of carriers for dry powder inhalers"

Teaching and Supervisory Responsibilities

MPharm

Unit Leader:

  • Transport 2 Module, Urinary Problems Unit
  • Patient Centred Care Module, Evidence Based Practice Unit

Unit Team Member:

  • Nutrition Metabolism Reproduction 1 Module, Reproduction Unit
  • Nutrition Metabolism Reproduction 1 Module, Gastrointestinal Tract Unit
  • Senses Thoughts and Movements Module, Skin Problems Unit
  • Transport 2 Module, Respiratory Problems Unit

Personal Academic Tutor

Student Selected Component- Supervisor

Student Selected Assignment- Supervisor

MSc Pharmaceutical Technology

Module Member:

  • Sciences of Solid Dosage Forms and Advanced Pharmaceutical Technologies Module
  • Fundamentals of Drug Delivery
  • Computational Pharmaceutics

Administrative Responsibilities

Postgraduate Research Coordinator

Biography

Krzysztof J. Paluch joined University of Bradford as a Lecturer in Medicines Development and Pharmaceutical Sciences.

He holds an MSc in Pharmacy from Jagiellonian University Krakòw (2005) and Ph.D. in Pharmaceutical Sciences from Trinity College, University of Dublin (2011). He is a Project Management Associate (Irish Institute Project Management Ireland, 2012).

His research interests focus on: screening and characterization of novel salts and co-crystals, characterization of amorphous forms, nanoparticles and spray dried microparticles.

His collaborations include projects with: Trinity College Dublin, University of Silesia, University of Gdansk and others.

To date, his research was funded by: Irish Research Council for Science, Engineering and Technology and Science Foundation Ireland.

Study History

2005: M.Sc. in Pharmacy, Jagiellonian University of Kraków
2011: Ph.D. in Pharmaceutical Sciences, Trinity College, University of Dublin
2012: Project Management Associate, Irish Institute Project Management Ireland
2015: Associate of Higher Education Academy UK, University of Bradford

Professional History

2013-2014: Postdoctoral Research Fellow, Identification and Control of Critical API Characteristics for Robust Drug Product Production and Performance Solid State and Synthesis Pharmaceutical Cluster, University of Limerick. School of Pharmacy and Pharmaceutical Sciences, Trinity College, University of Dublin.

2011-2013: Postdoctoral Research Fellow, Active Pharmaceutical Ingredient-Formulation Interface, Solid State Pharmaceutical Cluster, University of Limerick. School of Pharmacy and Pharmaceutical Sciences, Trinity College, University of Dublin.

2005-2006: Research Assistant, Department of Pharmaceutical Technology and Biopharmaceutics, School of Pharmacy, Collegium Medicum, Jagiellonian University of Krakow.

2005-present: Community Pharmacist.

Professional Activities

  • Member of Higher Education Academy UK
  • Member of General Pharmaceutical Council UK
  • Member of Centre for Pharmacy Postgraduate Education UK
  • Member of International Association of Project Managers
  • Member of American Association of Pharmaceutical Scientists
  • Member of Pharmaceutical Society of Ireland
  • Member of Polish Pharmaceutical Chamber

Research Areas

  • Solid-state and micromeritic characterisation of spray dried microparticles
  • Physicochemical characterisation of high-energy forms of active pharmaceutical ingredients
  • Nanoparticulate-based delivery systems
  • New salts and co-crystalline forms screening and characterisation

Current Projects

  • Impact of intermolecular interactions on quantitative heat induced evaporative nano-co-precipitation, 2015-2016, The Royal Society Research Grant
  • Impact of coformer on parallel artificial membrane permeability profile of active pharmaceutical ingredients, 2015-2016, Bradford School of Pharmacy Start Up Grant

Research Collaborations

  • Prof. Lidia Tajber, Trinity College, Dublin
  • Prof. Marian Paluch, University of Silesia
  • Prof. Anant Pardkar, University of Bradford
  • Dr Khaled Assi, University of Bradford
  • Dr Dolores Serrano Lopez, University of Mardid
  • Dr Colin Seaton, University of Bradford

Publications

  • Zaneta Wojnarowska, Krzysztof J Paluch, Evgeni Shoifet, Christoph Schick, Lidia Tajber, Justyna Knapik, Patryk Wlodarczyk, Katarzyna Grzybowska, Stella Hensel-Bielowka, Sergey P Verevkin, Marian Paluch, Molecular origin of enhanced proton conductivity in anhydrous ionic systems. Journal of the American Chemical Society. 2015, 137, 3, 1157-1164
  • DR Serrano, P O'Connell, KJ Paluch, D Walsh, AM Healy. Cocrystal habit engineering to improve drug dissolution and alter derived powder properties Journal of Pharmacy and Pharmacology 2015, DOI: 10.1111/jphp.12476
  • Matthias Manne Knopp, Lidia Tajber, Yiwei Tian, Niels Erik Olesen, David S Jones, Agnieszka Kozyra, Korbinian Löbmann, Krzysztof Paluch, Claire Marie Brennan, René Holm, Anne Marie Healy, Gavin P Andrews, Thomas Rades Comparative Study of Different Methods for the Prediction of Drug–Polymer Solubility, Molecular pharmaceutics. 2015, 12, 9, 3408-3419
  • Anita Umerska, Krzysztof Jan Paluch, Maria Jose Santos-Martinez, Carlos Medina, Owen I Corrigan, Lidia Tajber Chondroitin-based nanoplexes as peptide delivery systems–Investigations into the self-assembly process, solid-state and extended release characteristics European Journal of Pharmaceutics and Biopharmaceutics. 2015, 93, 242-253
  • M Dul, KJ Paluch, H Kelly, AM Healy, A Sasse, L Tajber, Self-assembled carrageenan/protamine polyelectrolyte nanoplexes—Investigation of critical parameters governing their formation and characteristics Carbohydrate polymers. 2015, 123, 339-349
  • Christine Grossjohann, Dolores R Serrano, Krzysztof J Paluch, Peter O'Connell, Liana Vella‐Zarb, Panagiotis Manesiotis, Thomas Mccabe, Lidia Tajber, Owen I Corrigan, Anne Marie Healy, Polymorphism in Sulfadimidine/4‐Aminosalicylic Acid Cocrystals: Solid‐State Characterization and Physicochemical Properties. Journal of Pharmaceutical Sciences. 2015, 104, 4, 1385-1398
  • T Zhang, K Paluch, G Scalabrino, N Frankish, AM Healy, H Sheridan. Molecular structure studies of (1S, 2S)-2-benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol. Journal of Molecular Structure. 2015, 1083, 286-299
  • Z. Wojnarowska, Y. Wang, K.J. Paluch, A.P. Sokolov, M. Paluch. Observation of highly decoupled conductivity in protic ionic conductors. Phys. Chem. Chem. Phys. 2014, 16(19), 9123-9127
  • Paluch K.J., McCabe T., Müller-Bunz H., Corrigan O.I., Healy A.M., Tajber L. Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid. Mol. Pharm. 2013, 10(10), 3640-54
  • Wojnarowska Z., Grzybowska K., Hawelek L., Dulski M., Wrzalik R., Gruszka I., Paluch M., Pienkowska K., Sawicki W., Bujak P., Paluch K.J., Tajber L., Markowski J. Molecular dynamics, physical stability and solubility advantage from amorphous indapamide drug. Mol. Pharm. 2013, 10(10), 3612-27
  • Paluch, K.J., Tajber, L., Corrigan, O.I., and Healy, A.M., A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability, Int. J. Pharm. 2012, 436(1-2), 873-6
  • Paluch, K.J., Tajber, L., Elcoate, C.J., Corrigan, O.I., Lawrence, S.E., Healy A.M., Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt, J. Pharm. Sci. 2011, 100(8), 3268-3283
  • Paluch, K.J., Tajber, L., McCabe, T., O’Brien, J.E., Corrigan, O.I., Healy, A.M., Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure, Eur. J. Pharm. Sci. 2010, 41(5), 603 – 611

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