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Dr Xiangli Liu

PositionLecturer in Medicines Development and Pharmaceutical Sciences
Location2.12 Norcroft building
DepartmentBradford School of Pharmacy
Telephone+44 (0) 1274 236077
EmailX.Liu18@bradford.ac.uk

Research Interests (key words only)

Drug delivery, skin, biomembrane, liposome

Teaching and Supervisory Responsibilities

  • PH-1219L (Capability in Pharmacy 1)
  • PH-1216U Unit 3 (Drug administration and absorption)
  • PH-1216U Unit 5 (Drug distribution and metabolism)
  • PH-2228U Unit 4 (Integrated system)
  • PH-2230L (Maths for Pharmacists stage 2)
  • STM1 Units 1 and 2 (Skin System)
  • STM2 Unit 2 (Skin System)

Biography

After getting my PhD in pharmaceutical sciences in University of Lausanne, Switzerland, I pursued my postdoctoral work in Japan and Germany, gained research experience in the fields in drug-biomembrane interactions, transdermal delivery and quantitative structure-skin permeation relationship of drugs. A number of papers on these research areas were published in peer-reviewed international journals. In addition to the research, as a lecturer, I also got teaching experience in pharmaceutical sciences and supervised/co-supervised 3 PhD students during my tenure in university Jena, Germany. In March 2011, I received the German academic grade “Habilitation” required to obtain an academic lectureship. 

Study History

Habilitation in Pharmaceutical Sciences, Friedrich-Schiller-University Jena, Germany 2011

Ph.D. in Pharmaceutical Sciences, University of Lausanne, Switzerland 2003

Professional History

Nov 2006 - Jul 2013: Lecturer and Senior researcher, Department of Pharmaceutical Technology, Friedrich-Schiller-University Jena, Germany.  Active in teaching and research. The main research areas were (1) Drug skin delivery by liposomal formulations, (2) Drug-biomembrane interactions by using liposomes as model membranes and (3) Quantitative structure-skin permeation relationships.

Nov 2003 - Dec 2005: 21st Century COE Research Scientist, Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Research on physicochemical profiling and quantitative structure-pharmacokinetics relationship of of pharmaceuticals and flavonoids.

Sept 1999 - Sept 2003: Researcher, Institute of Medicinal Chemistry, University of Lausanne, Switzerland.  Research topic was "New approaches to measure lipophilicity: application and interpretation."

Research Areas

  • Dermal and transdermal drug delivery 
  • Drug-biomembrane interactions by using liposomes as model membranes
  • Quantitative structure-pharmacokinetics relationships of drugs

Current Projects

  • Mechanisms of drug interaction with biomembranes
  • Transdermal and dermal drug delivery

Publications

  • Michael H Abraham, Joelle MR Gola, Adam Ibrahim, William E. Acree Jr, Xiangli Liu. The prediction of blood-tissue partitions, water-skin partitions and skin permeation for agrochemicals, Pest Manag Sci. DOI 10.1002/ps.3658 (2013)
  • Michael H Abraham, William E. Acree Jr, Alfred Fahr, Xiangli Liu. Analysis of immobilized artificial membrane retention factors for both neutral and ionic species, J Chromatogr. A, 1298, 44-49 (2013)
  • Keda Zhang, Ming Chen, Gerhard Scriba, Michael H. Abraham, Alfred Fahr, Xiangli Liu. Human skin permeation of neutral species and ionic species: extended linear free-energy relationship analyses, J. Pharm. Sci., 101, 2034-2044 (2012)
  • Kewei Yang, Burkhard Gitter, Ronny Rüger, Gerhard D. Wieland, Ming Chen, Xiangli Liu, Volker Albrecht, Alfred Fahr, Antimicrobial peptide-modified liposomes for bacteria targeted delivery of temoporfin in photodynamic antimicrobial chemotherapy. Photochemical & Photobiological Science, 10, 1593-1601 (2011)
  • Keda Zhang, Ming Chen, Gerhard Scriba, Michael H. Abraham, Alfred Fahr, Xiangli Liu. Linear free energy relationship (LFER) analysis of retention factor in cerasome electrokinetic chromatography intended for predicting drug skin permeation, J. Pharm. Sci., 100, 3105-3113 (2011)
  • Hossam Hefesha, Stephan Loew, Xiangli Liu, Sylvio May, Alfred Fahr, Transfer Mechanism of Temoporfin between Liposomal Membranes, J. Control. Rel., 150, 279-286 (2011)
  • Peter van Hoogevest, Xiangli Liu, Alfred Fahr, Drug delivery strategies for poorly water-soluble drugs from the industrial perspective, Expert. Opin. Drug Deliv. 8, 1481-1500 (2011)
  • Xiangli Liu, Bernard Testa, Alfred Fahr. Lipophilicity and its relationship with passive drug permeation, Pharm. Res., 28, 962-977 (2011)
  • Peter van Hoogevest, Xiangli Liu, Alfred Fahr, Mathew L.S. Leigh. Role of phospholipids in the oral and parenteral delivery of poorly water soluble drugs, J. Drug Del. Sci. Tech., 21(1), 5-16 (2011)
  • Ming Chen, Xiangli Liu, Alfred Fahr. Skin penetration and deposition of CF and mTHPC from different lipid vesicles--finite and infinite dosage application, Int. J. Pharm., 408, 223-234 (2011)
  • Ming Chen, Xiangli Liu, Alfred Fahr. Skin delivery of ferulic acid from different liposomal systems, Journal of Biomedical Nanotechnology, 6, 577-585 (2010)
  • Jiantao Zhang, Silvia Petersen, Mahendra Thunga, E Leipold, Roland Weidisch, Xiangli Liu, Alfred Fahr, & Klaus D. Jandt. Micro-Structured Smart Hydrogels with Enhanced Protein Loading and Release Efficiency, Acta Biomater, 6, 1297-1306 (2010)
  • Xiangli Liu, Ping Fan, Ming Chen, Gerhard K.E. Scriba, Detlef Gabel, Alfred Fahr. Drug-membrane interaction on immobilized liposome chromatography compared to immobilized artificial membrane (IAM), liposome/water and n-octanol/water systems, Helv. Chim. Acta, 93, 203-211 (2010)

 

 

 

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