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Do Advanced Glycation End-products (AGEs) stimulate thrombosis by blocking prostaglandin E1-mediated inhibition of platelet adhesion and spreading?

Summary of project

Patients with Type 2 diabetes mellitus (T2DM) have a significantly increased risk of having a heart attack or stroke. Therefore additional treatment options are urgently required which can limit thrombosis and improve outcomes for T2DM patients. Heart attacks and strokes occur due to rapid formation of a platelet-rich blood clot or “thrombus” that blocks blood flow in major vessels. This is due partly to reduced activity of protective signalling pathways that limit platelet activation and thrombus formation in T2DM. However the mechanisms responsible remain unknown. Therefore, identifying how T2DM increases patient risk of heart attack or stroke will be critical for designing new targeted therapeutics to rescue platelet function in these patients.

In this PhD project you will pursue an integrated programme of work to test the hypothesis that advanced glycation end-products (AGEs) linked with mortality in T2DM can promote platelet thrombus formation by reducing the activity of protective signalling pathways that normally limit platelet activation. Once you have characterised these functional responses, you will then use cutting edge biochemical and pharmacological approaches to identify the underlying molecular mechanisms.

Entry requirements

2:1 honours in a relevant Bachelors degree or relevant Masters degree.

Funding

Applicants will need to have their own funding or external sponsorship. A bench fee will be payable in addition to the tuition fees.

Supervisors

Title and name:
Dr Wayne Roberts
Position:
Lecturer in Medical Sciences
Email address:
Telephone number :
Work+44 (0) 1274 232131
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Title and name:
Professor Tim Palmer
Position:
Professor of Pharmacology, Head of Pharmacology and Experimental Therapeutics
Email address:
Telephone number :
Work+44 (0) 1274 234662
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See the PhD (School of Pharmacy and Medical Sciences) course page to find out more about studying at the University of Bradford, including fees, how to apply, facilities, and the support available to you.