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Crystal engineering of pharmaceuticals: Improving chemical stability and manufacturability of active ingredients by formation of cocrystals

Summary of project

Drug development and commercialization success primarily depends on active pharmaceutical ingredient (API) manufacturability, stability and bioavailability. A significant fraction of APIs, with desired therapeutic activities, are found to pose quality, efficacy and safety issues due to poor physicochemical and photostability during processing, storage, packaging and on the oral dosage form. Cocrystallisation is an emerging area of crystal design which showed promising advantages in the pharmaceutical space. Currently, the pharma industry is keen on evaluating the potential of the cocrystal approach for improved medicines.

This project is focused on the chemical stability and manufacturability of active ingredients for the sustainable and safe drugs. It will involve crystal and particle engineering and pharmaceutical technologies for cocrystallisation and drug development. During the programme, the student’s innovative ideas are highly encouraged.


Entry requirements

MSc or Bachelors (2:1 or above) in Pharmaceutical Science, Chemistry, Food/ Materials Science, Physics or related areas.


Supervisors

Title and name:
Dr Venu Vangala
Position:
Lecturer in Medicines Development and Pharmaceutical Science
Email address:
Telephone number :
Work+44 (0) 1274 236116
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Title and name:
Professor Anant Paradkar
Position:
Professor of Pharmaceutical Engineering Science
Email address:
Telephone number :
Work+44 (0) 1274 233900
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Title and name:
Dr Colin Grant
Position:
Lecturer in Medical Engineering
Email address:
Telephone number :
Work+44 (0) 1274 234550
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See the PhD (School of Pharmacy and Medical Sciences) course page to find out more about studying at the University of Bradford, including fees, how to apply, facilities, and the support available to you.