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HOX proteins as therapeutic targets in mesothelioma

Summary of project

This PhD involves the development of novel therapies and diagnostics in mesothelioma, a type of cancer that often occurs in the lungs and has a very poor prognosis. Our previous work showed that the HOX genes, a family of transcription factors with key roles in early development, are generally overexpressed in mesothelioma. Furthermore, a peptide (HXR9) that blocks the interaction between HOX proteins and their PBX cofactor prevents the growth of mesothelioma tumours, and the expression of a subset of HOX genes accurately predicts the sensitivity of tumours to HXR9. The objectives of this new study are to further understand how mesothelioma can be treated using HOX/PBX inhibitors, and how HOX proteins and RNA transcripts can act as potential diagnostic markers for this disease.

You will be based at the Institute for Cancer Therapeutics in the School of Pharmacy and Medical Sciences, University of Bradford, an internationally competitive research centre that provides a supportive environment and has an excellent track record in PhD training and completion, and a thriving postgraduate student community. Training in the first year will include standard cell and molecular biology techniques as well as more advanced methodology including confocal and florescent microscopy.  You will also be supported by an active, ongoing education program of seminars and student-led events.

Entry requirements

2:1 honours in a Bachelors, or Masters degree, in a relevant subject area.

Funding

Applicants will need to have their own funding or external sponsorship. A bench fee will be payable in addition to the tuition fees.

Supervisors

Title and name:
Professor Richard Morgan
Position:
Director, Institute of Cancer Therapeutics and Professor of Molecular Oncology
Email address:
Telephone number :
Work+44 (0) 1274 233235
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Title and name:
Dr Steve Shnyder
Position:
Senior Lecturer in Tumour Biology
Email address:
Telephone number :
Work+ 44(0) 1274 235898
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See the PhD (School of Pharmacy and Medical Sciences) course page to find out more about studying at the University of Bradford, including fees, how to apply, facilities, and the support available to you.