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Mechanochemistry of solid dispersions produced by co-current processing- spray drying and hot-melt extrusion

Project summary

The production of the binary or ternary solid dispersions is one of the methods of improving of physicochemical properties of an active pharmaceutical ingredient (API), such as (for example) an apparent solubility or thermal physical stability. Solid dispersions can be produced by spray drying (SD) or hot melt extrusion (HM). The impact of mechanical stress on physical stability of ternary heterogenic solid dispersions has not, to date, been widely investigated in the pharmaceutical field.

The project is focused on understanding of impact of mechanical stress, such as (for example): mechanical impaction, pressure, shear, cavitation on physicochemical properties of poly-phase and homogenous solid dispersions produced by SD and HM.

Entry requirements

MSc or Bachelor's degree (2:1 or above) in Chemistry, Physics, Pharmaceutical Sciences, Material, Food Science.


Title and name:
Dr Krzysztof Paluch
Lecturer in Medicines Development and Pharmaceutical Science
Email address:
Telephone number :
Work+44 (0) 1274 236110
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