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Synthetic applications of cyclobutane chemistry

Summary of Project:

The cyclobutane skeleton is present in a number of natural products with interesting structure and biological properties, including nigramides, penitrems, sceptrin, providencin and santiaguine. These molecules form an important source of lead compounds for drug development, but pose a significant challenge to synthetic and medicinal chemists. There are few straightforward methods for cyclobutane synthesis, particularly when chiral compounds are required.

This project aims to explore and expand the scope of a new method for the synthesis of highly functionalised cyclobutanes. It will be applied to the synthesis of natural products, and other molecules of medicinal and pharmaceutical interest.

Entry requirements:

At least 2.i Honours degree or equivalent in Chemistry (or Natural Sciences with Part III Chemistry), preferably with research experience (undergraduate project/placement, or subsequent work experience) in synthetic organic or medicinal chemistry.

Funding

Applicants will be expected to provide their own funding or external sponsorship. A bench fee of £5,000 will be applicable to this project, in addition to the tuition fees.

Supervisors:

Title and name:
Dr Helen Sheldrake
Position:
Lecturer in Organic and Medicinal Chemistry
Email address:
Telephone number :
Work+44 (0) 1274 236858
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Title and name:
Professor Laurence Patterson
Position:
Professor of Drug Discovery
Email address:
Telephone number :
Work+44 (0) 1274 233226
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See the PhD (School of Pharmacy and Medical Sciences) course page to find out more about studying at the University of Bradford, including fees, how to apply, facilities, and the support available to you.