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Dr Goreti Morais

PositionPost-doc Research Assistant
LocationICT building
DepartmentInstitute of Cancer Therapeutics
Telephone+44 (0) 1274 235894
EmailG.Ribeiromorais@bradford.ac.uk

Research Interests (key words only)

Medicinal Chemistry, Organic Chemistry, Molecular Imaging

Study History

  • PhD Thesis in Pharmacy, University of Lisbon, Portugal ( Nov 2006)
  • PhD studies, University of Coimbra, Coimbra, Portugal/University of Kyushu, Fukuoka, Japan (2002-2006)
  • PGDipPharm, Faculty of Pharmacy, University of Coimbra, Portugal (2000)

Professional History

  • Senior Post-Doctoral Fellow, Institute of Cancer Therapeutics, University of Bradford, England (2014-present)
  • Research Associate, Radiopharmaceutical Science Group, Campus Technologic and Nuclear, Portugal (2009-2014)
  • Post-Doctoral Research Assistant, Institute of Cancer Therapeutics, University of Bradford, England (2006-2009)
  • Staff Pharmacist at the Community Pharmacy “Vasco da Gama”, Portugal (2001-2002)

Research Areas

I have been working at the interface of chemistry and biology and have developed skills ranging from Organic Chemistry, Medicinal Chemistry, Radiochemistry and Molecular Imaging. In Oct 2014, I returned to the ICT as Post-Doc to support the organic synthesis requirements across the Yorkshire Cancer Research Medicines Discovery programme. Precisely, I am participating in the:

  • Development of duocarmycin synthetic derivatives as CYPs activated prodrugs
  • Development of small molecule polysialyltransferase inhibitors as potential anti-metastatic agents

Also, I have a leading role in developing chemical imaging tools to probe biological systems.

Current Projects

Team member of the project: "Cancer Medicines Discovery", Yorkshire Cancer Research funded: Patterson, L.H. (P.I.), Falconer, R.A.; Pors, K.; Afarinkia, K.; Loadman, P.M.; Shnyder S.D.

Publications

  • Ribeiro Morais G, Springett BR, Pauze M, Schroeder L, Northrop M, Falconer RA "Novel strategies for the synthesis of unsymmetrical glycosyl disulfides" Org Biomol Chem 2016, 14, 2749 - 2754
  • Ribeiro Morais G, Palma E, Marques F, Gano L, Oliveira MC, Abrunhosa A, Miranda HV, Outeiro TF, Santos I, Paulo A "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutics Agents" J Heterocyclic Chem, 2016 accepted doi: 10.1002/jhet.2575
  • Nunes P, Ribeiro Morais G, Palma E, Silva F, Oliveira MC, Ferreira VFC, Mendes F, Gano L, Miranda H V, Outeiro TF, Santos I, Paulo A "Isostructural Re(I)/99mTc(I) Tricarbonyl Complexes Functionalized with Benzothiazole Derivatives for Cancer Theranostic" Org Biomol Chem 2015 13: 5182
  • Gill J, Loadman P, Shnyder S, Cooper P, Atkinson J, Ribeiro Morais G, Patterson L, Falconer RA "The Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity Against Solid Tumors and Reduced Potential For Cardiovascular Toxicity" Molecular Pharmaceutics, 2014 11(4): 1294-1300
  • Al-Saraireh Y M J, Sutherland M, Springett B R, Ribeiro Morais G, Loadman P M, Errington T J, Smith P J, Patterson L H, Shnyder S D, Falconer R A "Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration" Plos One 2013, 8(8):e73366
  • Ribeiro Morais G, Kniess T, Bergmann R, Gano L, Abrunhosa A, Santos I, Paulo A "Radiosynthesis and in vivo Evaluation of a 18F-Labelled Styryl-Benzoxazole Derivative for beta-Amyloid Targeting" Appl Rad Isotopes 2013, 82, 100-104
  • Ribeiro Morais G, Falconer R A; Santos I "Carbohydrate-based molecules suitable for nuclear molecular imaging" Eur J Org Chem 2013, 1401-1414 (Cover Picture)
  • Oliveira M C, Neto C, Ribeiro Morais G, Thiemann T "Steroid receptor ligands for breast cancer targeting: an insight into their potential role as PET imaging agents" Curr Med Chem, 2013 20 (2), 222-245
  • Ribeiro Morais G, Santos I C, Santos I, Paulo A "X-ray diffraction structures of regioisomers of N-methylated benzimidazole compounds with interest for the synthesis of amyloid probes" J Chem Crystallogr 2012, 42, 1052-1059
  • Ribeiro Morais G, Paulo A, Santos I "Organometallic complexes for SPECT Imaging and/or Radionuclide Therapy" Organometallics 2012, 31, 5693-5714
  • Ribeiro Morais G, Paulo A, Santos I "A synthetic overview of radiolabeled compounds for β-amyloid targeting" Eur J Org Chem, 2012, 1279-1293 (Cover Picture)
  • Ribeiro Morais G, Miranda H V, Santos I C, Santos I, Outeiro T F, Paulo A, "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes" Bioorg Med Chem, 2011, 19, 7698-7710
  • Ribeiro Morais G, Felix Oliveira I, Humphrey A J, Falconer R A "Identification of an acetyl disulfide derivative in the synthesis of thiosialosides." Carbohyd. Res, 2010, 345, 160-162

Book chapter

  • A Paulo, G Ribeiro Morais, I Santos (2013) "Organometallic Chemistry of Rhenium and Technetium Fuelled by Biomedical Applications" In Advances in Organometallic Chemistry and Catalysis, Armando J. L. Pombeiro (Ed.), ISBN: 9781118510148, John Wiley & Sons, Inc

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