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Dr Victoria Vinader

PositionLecturer in Drug Toxicology and Safety Pharmacology
Location2.20, ICT building
DepartmentInstitute of Cancer Therapeutics
Telephone+44 (0) 1274 233205
EmailM.Vinader@bradford.ac.uk
LinkedInVisit my LinkedIn profile

PhD Supervision

Joint supervision PhD students with Dr Kamyar Afarinkia:

  • Oluwakemi Folaranmi
  • Devjedt Ahmet
  • Haneen Basheer
  • Rima Mroueh
  • Mohamed Anees
  • Mashael Abdullah 

Teaching and Supervisory Responsibilities

Course leader: MSc Drug Toxicology & Safety Pharmacology

Module Leader

  • Research Project in Safety Pharmacology
  • Critical appraisal of a current topic in Safety Pharmacology
  • Molecular mechanisms of toxicity

Lecturer and Projects

  • Practical lecturer for Research and Analytical Methods in Pharmacology Module
  • Lecturer for Chemistry and Forensic Sciences, Principles of Pharmacology and Toxicology
  • Lecturer for Biomedical Sciences Y3 R-Topics in Cancer Biology and Therapeutics, - R-Topics in Medical Biochemistry, - R-Topics in Medical Cell Pathology
  • Project supervisor for Y3 Biomedical Sciences research project 

Administrative Responsibilities

  • Course leader and Tutor: MSc Drug Toxicology & Safety Pharmacology

Study History

  • PhD (Cum Laude) and BSc (First Class Hons) University of Murcia, Spain (1990)
  • Fulbright Fellow, John Hopkins University, Baltimore, USA (1990-1992)

Professional History

  • Senior Investigator, GlaxoSmithKline, Medicinal Chemistry Department Stevenage, Hertfordshire (1992-2006)

Professional Activities

  • Member of American Chemical Society (1991)
  • Author of over 40 research papers and numerous conference presentations, plus two book chapters and 5 review articles.
  • Grant reviewer for EPSRC

Research Areas

  • Synthetic organic synthesis
  • Drug discovery and Medicinal Chemistry
  • Modulation of chemokine signalling and its potential for anti-metastatic therapy
  • Modulation of formylpeptide receptor signalling and identification of novel anticancer molecules with potential for inhibiting the migration and invasion of brain tumour cells, with a specific focus on the stem cell niche
  • Modulation of metastatic pathways
  • Computational chemistry and molecular modelling

Current Projects

  • Modulation of chemokine signalling and its potential for anti-metastatic therapy
  • Modulation of formylpeptide receptor signalling and identification of novel anticancer molecules with potential for inhibiting the migration and invasion of brain tumour cells, with a specific focus on the stem cell niche

Networks/Roles

  • Computational chemistry and molecular modelling
  • Point of contact for new medicinal chemistry collaborations

Publications

Publications are also listed in Bradford Scholars here

  1. Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines. Ahmed M.; Basheer, H.A.; Ayuso, J. M.; Ahmet, D.; Mazzini, M.; Patel, R.; Shnyder, S. D.; Vinader, V. Afarinkia, K.  Scientific Reports, 7(1), 1075 (2017).
  2. The role of substituents in retro Diels-Alder extrusion of CO2 from 2(H)-pyrone cycloadducts. Haji Abdullahi, M.; Thompson, L. M.; Bearpark, M. J. Vinader, V. Afarinkia, K. Tetrahedron, 72, 6021-6024 (2016).
  3. Study of the Chemotactic Response of Multicellular Spheroids in a Microfluidic Device. Jose M. Ayuso, Haneen A. Basheer, Rosa Monge, Pablo Sánchez-Álvarez, Manuel Doblaré, Steven D. Shnyder, Victoria Vinader, Kamyar Afarinkia, Luis J. Fernández, Ignacio Ochoa. PLOS ONE published 07 Oct 2015. 10.1371/journal.pone.0139515
  4. Probing Cytochrome P450-mediated activation with a truncat-ed azinomycin analogue. Victoria Vinader, Maria Sadiq, Mark Sutherland, Mengying Huang, Paul M. Loadman, Lina Elsalem, Steven D. Shnyder, Hongjuan Cui, Kamyar Afarinkia, Mark Searcey, Laurence H. Patterson, Klaus Pors. Med. Chem. Commun., 2015, 6, 187–191
  5. Synthesis of a Pseudo-Disaccharide Library and Its Application to the Characterisation of the Heparanase Catalytic Site. Victoria Vinader, Mohamed H. Haji-Abdullahi, L. H. Patterson, Kamyar Afarinkia, PLOS ONE, published 18 Nov 2013. 10.1371/journal.pone.0082111
  6. Discovery and Computer Aided Potency Optimization of a Novel Class of Small Molecule CXCR4 Antagonists. Victoria Vinader, Djevdet S. Ahmet, Mohaned S. Ahmed, Laurence H. Patterson, Kamyar Afarinkia, PLOS ONE, published 18 Oct 2013.| 10.1371/journal.pone.0078744
  7. Carbasugar Probes to Explore the Enzyme Binding Pocket at the Anomeric Position: Application to the Design of Golgi Mannosidase II Inhibitors. V. Vinader, M.; Afarinkia, K. Current Medicinal Chemistry., 2013 20, (30), 3797-3801
  8. Isolation and Characterisation of All Four Diastereomeric Intermediates From a Horner-Wittig Reaction. Parry, Laura J.; Vinader, Victoria; Scowen, Ian J.; Patel, Vipul K.; Afarinkia, Kamyar. Phosphorus, Sulfur and Silicon and the Related Elements. 2013, 188, 195-199
  9. Synthesis and Biological Evaluation of Colchicine B-Ring Analogues Tethered with Halogenated Benzyl Moieties. Laura Cosentino , Mariano Redondo-Horcajo, Ying Zhao, Ana Rita Santos, Kaniz F. Chowdury ,Victoria Vinader, Qasem M. A. Abdallah , Hamdy Abdel-Rahman , Jérémie Fournier-Dit-Chabert ,Steven D. Shnyder , Paul M. Loadman , Wei-shuo Fang , José Fernando Díaz , Isabel Barasoain, Philip A. Burns, and Klaus Pors. Journal of Medicinal Chemistry. 2012, 55(24), 11062-11066
  10. Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation Jérémie Fournier-Dit-Chabert, Victoria Vinader, Ana Rita Santos, Mariano Redondo-Horcajo, Aurore Dreneau, Ramkrishna Basak, Laura Cosentino, Gemma Marston, Hamdy Abdel-Rahman, Paul M. Loadman, Steven D. Shnyder, José Fernando Díaz, Isabel Barasoain, Robert A. Falconer, Klaus Pors . Bioorganic & Medicinal Chemistry Letters. 2012, 22(24), 7693-7696
  11. An agarose spot chemotaxis assay for chemokine receptor antagonists. Vinader, V.; Al-Saraireh, Y.; Wiggins, H.L.; Rappoport, J.Z.; Shnyder, S.D.; Patterson, L.H.; Afarinkia, K. J. Pharmacol. Toxicol. Methods, 2011, 64, 213-216
  12. Cycloadditions of chiral carbonyl ylides with imine dipolarophiles as a route to enantiomerically pure α-amino-ß-hydroxy acids. Yu Gan, Laurence Harwood, Simon C. Richards, Ian E D Smith, Victoria Vinader. Tetrahedron Asymmetry. 2009, 20, 723-725
  13. Enantioselective synthesis of tetrafluorinated ribose and fructose. Linclau, Bruno; Boydell, A. James; Timofte, Roxana S.; Brown, Kylie J.; Vinader, Victoria; Weymouth-Wilson, Alexander C. Organic & Biomolecular Chemistry. 2009, 7(4), 803-814
  14. Oxazolidinones as novel human CCR8 antagonists. Jin J, Wang Y, Wang F, Kerns JK, Vinader VM, Hancock AP, Lindon MJ, Stevenson GI, Morrow DM, Rao P, Nguyen C, Barrett VJ, Browning C, Hartmann G, Andrew DP, Sarau HM, Foley JJ, Jurewicz AJ, Fornwald JA, Harker AJ, Moore ML, Rivero RA, Belmonte KE, Connor. Bioorganic & Medicinal Chemistry Letters. 2007, 17 (6), 1722-1725
  15. Dissociated nonsteroidal glucocorticoid receptor modulators; Discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine series. Barker M.; Clackers, M.; Copley, R.; Demaine, D.A.; Humphreys, D.; Inglis, G.G.A.; Johnston, M.J.; Jones, H.T.; Haase, M.V.; House, D.; Loiseau, R.; Nisbet, L.; Pacquet, F.; Skone, P.A.; Shanahan, S.E.; Tape, D.; Vinader, V.M.; Washington, M.; Uings, I.; Upton, R.; Mclay, I.M.; Macdonald, S.J.F. Journal of Medicinal Chemistry 2006, 49 (14), 4216-4231
  16. Conformational arm-wrestling: battles for stereochemical control in benzamides bearing matched and mismatched chiral 2- and 6-substituents. Clayden, J.; Foricher, Y.J.Y.; Helliwell, M.; Johnson, P.; Mitjans, D.; Vinader, V. Organic & Biomolecular Chemistry. 2006, 4 (3), 444-454
  17. Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through application of an “Agreement Docking” method. Barker, M.; Clackers, M.; Demaine, D.A.; Humphreys, D.; Johnston, M.J.; Jones, H.T.; Pacquet, F.; Pritchard, J.M.; Salter, M.; Shanahan, S.E.; Skone, P.A.; Vinader, V.M.; Uings, I.; McLay, I.M.; Macdonald, S.J.F. Journal of Medicinal Chemistry. 2005, 48 (14), 4507-4510

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