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Professor Paul Loadman

PositionChair of Drug Metabolism and Pharmacokinetics
LocationICT building 1.11
DepartmentSchool of Pharmacy and Medical Sciences, Institute of Cancer Therapeutics
Feedback HoursMon-Fri 8:00-18:00
Telephone+44 (0) 1274 233228
EmailP.M.Loadman@bradford.ac.uk

Teaching and Supervisory Responsibilities

  • Lectures: MSc in Cancer Pharmacology
  • Lectures: MSc in Drug Toxicology and Safety Pharmacology
  • Lectures: MSc in Cancer Drug Discovery
  • Lectures: MSc in Analytical Sciences
  • Lectures: BSc. & MSc Final Year: Research Topics in Cancer Biology I and II
  • Lectures: MSc Biomedical Science: Research & Analytical Methods
  • Lectures: BSc Second Year module: Clinical and Analytical Biochemistry
  • Lectures: BSc. Final Year: Research Project

Study History

PhD (Bradford), BSc Hons (CNAA), CBiol MRSB

Professional Activities

  • Member of the British Association for Cancer Research (Executive committee member)
  • Member of the Society of Biology
  • Member of the American Association for Cancer Research
  • Member of Pharmacokinetics and Molecular Mechanisms (PAMM) Group, EORTC
  • Member of the European Association for Cancer Research
  • Incanthera Ltd., - Co–founder and inventor

Research Areas

  • Pharmacokinetics and tumour drug metabolism of anti cancer drugs
  • Matrix metalloproteinases as targets for tumour-selective delivery of anticancer therapeutics
  • Drug delivery and prodrug design
  • Novel advances in analytical techniques. HPLC, GC, CE and LC/MS/MS
  • Drug interactions both in vitro and in vivo

Research Team

  • Amanda Race, Research Assistant
  • Antonia Wierzbicki, Research Assistant
  • Jade Spencer, Research Technician
  • Xiaoxiao Guo , Post-doctoral Research Assistant
  • Maria Jove Casulleras, Researcher
  • Greg Langton QA Manager

Postgraduate student supervision

  • PhD Rene Ankrah (Joint supervision with Dr Rob Falconer and Dr Steve Shnyder) PhD project: MT-MMP Expression in Head and Neck Cancer for Prodrug Development, funded by Yorkshire Cancer Research
  • PhD Jamal Elbakay (Joint supervision with Dr Rob Falconer)
  • PhD Sara Elkashef (Joint supervision with Dr Rob Falconer)
  • PhD Francis Mprah Barnieh (Joint supervision with Dr Rob Falconer)

Networks/Roles

  • Team Leader: DMPK
  • Management of DMPK and Clinical Pharmacology Group
  • Deputy Institute Safety Liaison Officer
  • Institute local education authority Nuffield placement liaison
  • Laboratory Coordinator of Phase I clinical trials
  • Person Designate for HTA licence

Publications

See Professor Loadman's publications on Bradford Scholars

101 full papers, 5 patents and 300+ refereed conference proceedings

Suchismita Mohanty, Zixin Chen, Kai Li, Goreti Ribeiro Morais, Jessica Klockow, Ketan Yerneni, Laura Pisani, Frederick T Chin, Siddharta Mitra, Samuel jCheshier, Edwin Chang, Sanjiv Sam Gambhir, Jianghong Rao, Paul M. Loadman, Robert A. Falconer, Heike E Daldrup-Link (2017), A novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival- , Molecular Cancer Therapeutics, 2017 16 (9) 1909-1921

M.E.Hubbard, M.Jove, P.M.Loadman, R.M.Phillips, C.J.Twelves S.W.Smye, Drug delivery in a tumour cord model: a computational simulation, (2017) Royal Society Open Science 4. DOI: 10.1098/rsos.170014 

Milene Volpato , Jade A Spencer , Amanda D Race , Alessandra Munarini, Andrea Belluzzi, Andrew J Cockbain, Mark A Hull, Paul M Loadman, A liquid chromatography-tandem mass spectrometry method to measure fatty acids in biological samples. J Chrom B (2017); Vol 1055-1056:p125-134

Mohit Jain, J. Jonathan Harburn, Jason H. Gill, Paul M. Loadman, Robert A. Falconer, Caitlin A. Mooney, Steven L. Cobb, David J. Berry, Rationalized Computer-Aided design of Matrix Metalloprotease-Selective Prodrugs., (2017) J. Med. Chem., 2017, 60 (10), pp 4496–4502, DOI: 10.1021/acs.jmedchem.6b01472

A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota , Henry Watson, Suparna Mitra, Fiona C Croden, Morag Taylor, Henry M Wood, Sarah L Perry, Jade A Spencer, Phil Quirke, Giles J Toogood, Clare L Lawton, Louise Dye, Paul M Loadman, Mark A Hull, Gut, Sep 2017, gutjnl-2017-314968; DOI: 10.1136/gutjnl-2017-314968

Practical aspects of pharmacokinetics and pharmacodynamics, Authors Chris Twelves, Maria Jove, Paul Loadman, Publication date 2015/3/20, Phase I Cancer Clinical Trials: A Practical Guide, Chapter 10, Oxford University Press, ISBN: 9780199359011

An optimised assay for quantitative, high-throughput analysis of polysialyltransferase activity Sara M. Elkashef, Mark Sutherland, Paul M. Loadman and Robert A. Falconer, (2016) The Analyst · August 2016 DOI: 10.1039/C6AN01073C

Wnt Signaling as a Therapeutic Target in Cancer and Metastasis, R. Morgan, R. Ankrah, S. El-Tanani, P. Loadman, L. Pattterson, P.S. Rudland, M. El-Tanani, Introduction to Cancer Metastasis, Chapter 20, http://dx.doi.org/10.1016/B978-0-12-804003-4.00020-7

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment, Sara M. Elkashef, , Simon J. Allison, , Maria Sadiq, , Haneen A. Basheer, Goreti Ribeiro Morais, Paul M. Loadman, Klaus Pors, & Robert A. Falconer, Scientific Reports 6, Article number: 33026 (2016) DOI: 10.1038/srep33026

Red blood cell membrane eicosapentaenoic acid (EPA) levels predict tumour EPA content and overall survival in a randomised, double-blind, placebo-controlled trial of EPA treatment in patients with colorectal cancer liver metastases, Henry Watson, Andrew J Cockbain, Jade Spencer, Amanda Race, Milene Volpato, Paul M Loadman, Giles J Toogood, Mark A Hull, (2016), Prostaglandins, Leukotrienes and Essential Fatty Acids (2016), Volume 115, Pages 60–66, DOI:http://dx.doi.org/10.1016/j.plefa.2016.10.003

Proteases in cancer drug delivery, Jennifer Vandooren, Ghislain Opdenakker, Paul M. Loadman, Dylan R. Edwards, Advanced Drug Delivery Reviews, (2016), 97,144–155 doi:10.1016/j.addr.2015.12.020

Probing cytochrome P450-mediated activation with a truncated azinomycin analogue, Victoria Vinader, Maria Sadiq, Mark Sutherland, Mengying Huang, Paul M. Loadman, Lina Elsalem, Steven D. Shnyder, Hongjuan Cui, Kamyar Afarinkia, Mark Searcey, Laurence H. Patterson and Klaus Pors, Med. Chem. Commun., 2015,6, 187-191

Thin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treated with the vascular disrupting agent DMXAA, Afnan Batubara, Vikki A Carolan, Paul M. Loadman, Chris Sutton, Steve D. Shnyder and Malcolm R. Clench Rapid Commun. Mass Spectrom. 2015, 29, 1–9

Andrew J Cockbain, Milene Volpato, Amanda D Race, Alessandra Munnarini, Chiara Fazio, Andrea Belluzzi, Paul M Loadman, Giles J Toogood, Mark A Hull, Anti-colorectal cancer activity of the omega-3 fatty acid eicosapentaenoic acid, (2014) Gut;63(11):1760-8

Jason H. Gill, Paul M. Loadman, Steven D. Shnyder, Patricia Cooper, Laurence H.Patterson, Jennifer M. Atkinson, Goretti Ribeiro Morais, Robert A. Falconer The Tumor-Targeted Vascular Disrupting Agent ICT2588 Demonstrates Therapeutic Activity Against Solid Tumours and Reduced Potential For Cardiovascular Toxicity.. (2014) Mol. Pharmaceutics, 11, 1294−1300

Piazzi, Giulia; D'argenio, Giuseppe; Prossomariti, Anna; Lembo, Vincenzo; Mazzone, Giovanna; Candela, Marco; Biagi, Elena; Brigidi, Patrizia; Vitaglione, Paola; Fogliano, Vincenzo; D'angelo, Leonarda; Fazio, Chiara; Munarini, Alessandra; Belluzzi, Andrea; Ceccarelli, Claudio; Chieco, Pasquale; Balbi, Tiziana; Loadman, Paul; Hull, Mark; Romano, Marco; Bazzoli, Franco; Ricciardiello, Luigi, Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota, (2014), International Journal of Cancer. 135(9):2004-13

Mathematical and Computational Models of Drug Transport in Tumours. C.M.Groh, M.E.Hubbard, P.F.Jones, P.M.Loadman, N.Periasamy, B.D.Sleeman, S.W.Smye, C.J.Twelves, R.M.Phillips, (2014), Journal of the Royal Society Interface,11(94)

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analogue Wong CC1, Periasamy N, Sagineedu SR, Sidik S, Sumon SH, Loadman PM, Phillips R, Lajis NH, Stanslas J., Investigational New Drugs.(2014),32(5):806-14

Prashant Kant, Sarah L Perry, Simon P Dexter, Amanda D Race, Paul M Loadman, Mark A Hull Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass, Obesity (2014), 22, 1, 202–210

Marie-Claude Djidja, Simona Francese, Emmanuelle Claude, Paul M Loadman, Chris Sutton, Steve Shynder, Patricia Cooper, Laurence H Patterson, Vikki A Carolan and Malcolm R. Clench, Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging, (2013), Current Analytical Chemistry. 9, 4 212- 225

Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH., Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder. Mol Cancer Ther. (2013);12(1):27-37

Mark A Hull, Anna C Sandell, Min Yang, Richard F A Logan, Gayle M Clifford, Colin J Rees, Paul M Loadman, Diane Whitham, A randomised controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma (or polyp) prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: The seAFOod (Systematic Evaluation of Aspirin and Fish Oil) Polyp Prevention Trial, (2013), Trials. 2013 Jul 29;14(1):237

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.Sheldrake HM, Travica S, Johansson I, Loadman PM, Sutherland M, Elsalem L, Illingworth N, Cresswell AJ, Reuillon T, Shnyder SD, Mkrtchian S, Searcey M, Ingelman-Sundberg M, Patterson LH, Pors K. (2013), J Med Chem. Aug 8;56(15):6273-7

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins Sandra Travica, Klaus Pors, Paul M. Loadman, Steve D. Shnyder, Inger Johansson, Mohammed N. Alandas, Helen M. Sheldrake, Souren Mkrtchian, Laurence H. Patterson, and Magnus Ingelman-Sundberg, (2013), Clinical Cancer Research;(19):2952-2961

Celina Ansari, Grigory A. Tikhomirov, Su Hyun Hong, Jason Gill, Robert Falconer, Paul M. Loadman, Rosalinda Castaneda, Florette K. Hazard, Ling Tong, Dean W. Felsher, Jianghong Rao, Heike E. Daldrup-Link, Development of Novel Activatable Theranostic Nanoparticles for combined Cancer MR Imaging and Therapy, (2013), Small., Volume 10, Issue 3, 417

Yousef M. J. Al-Saraireh, Mark Sutherland, Bradley R. Springett, Friedrich Freiberger, Goreti Ribeiro Morais, Paul M. Loadman, Rachel J. Errington, Paul J. Smith, Minoru Fukuda, Rita Gerardy-Schahn, Laurence H. Patterson, Steven D. Shnyder, and Robert A. Falconer, Inhibition of polysialyltransferase ST8SiaII by cytidine monophosphate modulates tumor cell migration, PLoS One 09 Aug (2013)

Sadr-ul-Shaheed, Nitin Rustogi , Andrew Scally, Julie Wilson, Helene Thygesen, Maria A. Loizidou, Andreas Hadjisavvas, Andrew Hanby, Valerie Speirs, Paul M. Loadman, Kyriacos Kyriacou, Chris W. Sutton, Identification of Stage-Specific Breast Markers using Quantitative Proteomics (2013), Journal of Proteome Research, 12 (12), pp 5696–5708

Hawcroft, G.; Volpato, M.; Marston, G.; Ingram, N.; Perry, S.; Cockbain, A.; Race, A.; Munarini, A.; Belluzzi, A.; Loadman, P.; Coletta, P; Hull, M., The ω-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of prostaglandin E2-dependent cell motility, B. J. of Pharmacology, (2012), 166, 5, 1724–37

Tomlinson DC, Baxter EW, Loadman PM, Hull MA, Knowles MA. FGFR1-Induced Epithelial to Mesenchymal Transition through MAPK/PLCγ/COX-2-Mediated Mechanisms. PLoS One. (2012);7(6)

Laura Cosentino, Mariano Redondo-Horcajo, Ying Zhao, Ana Rita Santos, Kaniz F. Chowdury, Victoria Vinader, Qasem M. A. Abdallah, Hamdy Abdel-Rahman, Jérémie Fournier-Dit-Chabert, Steven D. Shnyder, Paul M. Loadman, Wei-shuo Fang, José Fernando Díaz, Isabel Barasoain, Philip A. Burns, and Klaus Pors, Synthesis and Biological Evaluation of Colchicine B‑Ring Analogues Tethered with Halogenated Benzyl Moieties, J. Med. Chem., (2012), 55, (24), 11062-6

Fournier-Dit-Chabert J, Vinader V, Santos AR, Redondo-Horcajo M, Dreneau A, Basak R, Cosentino L, Marston G, Abdel-Rahman H, Loadman PM, Shnyder SD, Díaz JF, Barasoain I, Falconer RA, Pors K. Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation., Bioorg Med Chem Lett. 2012. Dec 15; 22(24):7693-6

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