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Dr Colin W Wright

PositionProfessor of Pharmacognosy
LocationM23b Richmond
DepartmentSchool of Pharmacy and Medical Sciences
Telephone+44 (0) 1274 234739
EmailC.W.Wright@bradford.ac.uk

Research Interests (key words only)

Natural products; pharmacognosy; protozoal diseases; malaria; natural anticancer agents; Chinese herbal drugs; synthesis of natural product analogues

Teaching and Supervisory Responsibilities

Undergraduate:

MPharm course - unit leader/ team member for the following units:

  • The structures of drugs (Foundation studies 2, unit 1, team member)
  • Key Reactions and Properties of Drug Molecules (Foundation studies 2, unit 2, team member)
  • Drug distribution, metabolism and excretion (Foundation studies 2, unit 4, unit leader)
  • Compliance and disposal (Foundation studies 2, unit 7, unit leader)
  • Diet and Introduction to metabolism (Nutrition, Metabolism and Reproduction I unit 1, unit leader)
  • Liver and drug metabolism (Nutrition, Metabolism and Reproduction I unit 7, unit leader)
  • Maths for pharmacists (Stage 1, unit leader)
  • Laboratory-based research project (Stage 4 student selected component, supervisor)

Other teaching contributions

  • Chemistry and Forensic Science, toxicology lectures
  • Medical Sciences, lectures on common diseases (malaria and TB)

 

 

Administrative Responsibilities

Supervisory roles:

  • Maths lead for M.Pharm course
  • Line manager of 7 academic staff in the Medicines Development and Pharmaceutical Sciences Research Group

Study History

  • 1975: B. Pharm. (Honours) in pharmacy, The School of Pharmacy, University of London
  • 1976: M.R.Pharm.S. Member of the Royal Pharmaceutical Society of Great Britain (undertaken within the Oxford Regional Health Authority)
  • 1979: M. Sc. in pharmacology with toxicology, University of East London (formerly the North East London Polytechnic)
  • 1989: Ph. D. in Pharmacognosy, (Antiamoebic and antimalarial natural products), The School of Pharmacy, University of London

 

Professional History

2016-present: Professor of Pharmacognosy

2004-2016: Reader in Pharmacognosy

2008-2011: Head of Division of Pharmaceutics and Pharmaceutical Chemistry

2002-present: Honorary Senior Lecturer in Pharmacognosy, The School of Pharmacy, University of London

2001-2004: Senior lecturer in Pharmacognosy, the School of Pharmacy, University of Bradford

1994-2001: Lecturer in Pharmacongosy, The School of Pharmacy, University of Bradford

1993-2002: Honorary Lecturer in Pharmacognosy, The School of Pharmacy, University of London

1992–1993: Research Fellow The School of Pharmacy, University of London

1993–1993: Lecturer in Pharmacognosy at The School of Pharmacy, University of London

1993-1994: Appointed by Pharmakon (Australia) initially on a consultancy basis (July-August 1993) to provide scientific advice and facilitate the licensing of Pharmakon products as medicines in the U.K. In addition I undertook various administrative tasks including the formation of a new company (Pharmakon U.K.).  From September 1993-April 1994 I was employed by the sister company  Pharmakon (USA) Inc. in a scientific capacity to liaise with the Medicines Control Agency in London  and work towards product licensing.

1989–1992: Maplethorpe Research Fellow in the Department of Pharmacognosy, The School of Pharmacy, University of London

1984–1985: Locum grade 1 pharmacist at Oldchurch Hospital, Romford, Essex.  Duties in clinical services with an emphasis on clinical pharmacy.  Frequently acting grade 2 pharmacist (in charge) at Rush Green Hospital, Romford, Essex

1982-1984: Studied theology and mission at All Nations Christian College, Ware, Herts.  Communications was an important element of the course.  Obtained the All Nations Christian College Diploma, and completed half the papers for the Cambridge Diploma in Religious Studies

1980-1982: Voluntary work in India for the Emmanuel Hospital Association, a Christian organisation responsible for 17 hospitals in North India aimed at providing rural health care.  The work involved upgrading and developing pharmacy services at Herbertpur Christian Hospital, Dist. Dehra Dun, U.P. and the promotion of the cost-effective and rational use of medicines. Duties included dispensing to outpatients and inpatients, preparation of intravenous fluids, eye drops, mixtures, ointments etc. Also visited some of the other hospitals run by the organisation to give advice and assistance with pharmaceutical matters.  During this time compiled "A guide to Drugs and Therapeutics", a publication designed to provide information for medical and nursing staff and to encourage rational prescribing of drugs and medicines

1980: Locum grade 1 pharmacist at the Royal Free Hospital, Hampstead

1978-1980: Pharmacist with the Boots Company. Dispensary manager and locum pharmacist in community pharmacies in East London

1976-1978: Grade 1 Pharmacist at King George Hospital, Ilford, Essex, and acting pharmacist in charge when required

1975–1976: Pre-registration pharmacist, Oxford Regional Health

Professional Activities

  • Editorial board member for:
    • Journal of Ethnopharmacology
    • Phytotherapy Research
    • Malaria Journal
  • External Examiner for undergraduate pharmacy course, Trinity College, Dublin, 2010/2011 to 2013/2014
  • Member of British Pharmacopoeia Commission Expert Advisory Group on Herbal Medicines, February 2011 to December 2014.
  • Member of the Academy of Pharmaceutical Scientists
  • Member of the British Society for Parasitology
  • Member of the Phytochemical Society of Europe
  • Member of the Royal Pharmaceutical Society of Great Britain
  • Registered as a pharmacist with the General Pharmaceutical Council

Research Areas

  • Natural Products, Pharmacognosy
  • Antiprotozoal and anticancer natural products
  • Anti-TB natural products
  • Synthesis of cryptolepine analogues as new leads to antiprotozoal and anticancer agents
  • Chinese herbal drugs

Current Projects

  • Investigation of West African plant species used traditionally for the treatment of malaria and/or cancer
  • Synthesis of cryptolepine analogues as antiprotozoal and anticancer agents
  • Chinese herbal antimalarials

Research Collaborations

Current collaborations include:

  • Professor Roger Phillips, Department of Pharmacy, University of Huddersfield. Investigation of anticancer natural products

  • Colleagues at the Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; research on traditional antimalarial plant species, especially Cryptolepis sanguinolenta
  • Dr Diego Munoz-Torrero, University of Barcelona; antiplasmodial activity of huprines
  • Professor Elisabeth Zhu, Institute of Social and Cultural Anthropology, University of Oxford; Chinese herbal antimalarials

Publications

Taiwo, B.J., Fatokun, A.A., Olubiyi, O.O., Bamiboye-Taiwo, O.T., van Heerden. F.R. and Wright, C.W. Identification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant Anacardium occidentale L. (Anacardiaceae). Bioorganic and Medicinal Chemistry 25:2327-2335, 2017.

Sola, I., Artigas, A., Taylor, M.C., Perez-Areales, F.J., Viayna, E., Clos, M.V., Perez, B., Wright, C.W., Kelly, J.M. and Munoz-Torrero, D. Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl- and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. Bioorganic Medicinal Chemistry 24:5162-5171, 2016.

Thota, S.P.R., Sarma, N.S., Murthy, Y.L.N., Kantamreddi, V.S.S. and Wright, C.W. A new embelin from the mangrove Aegiceras corniculatum. Indian Journal of Chemistry 55B:123-127, 2016.

Sola, I., Castella, Vianya, Galdeano, C., Taylor, M.C., Gbedema, S.Y., Perez, B., Clos, M.V. jones, D.C., Fairlamb, A.H., Wright, C.W., Kelly, J.M. and Munoz-Torrero, D. Synthesis, biological profiling and mechanistic studies of 4-amonoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. Bioorganic and Medicinal Chemistry 23:5156-5167, 2015.

Passreiter, C.M., Suckow-Schnitker, A-K., Kulawik, A., Addeae-Kyereme, J., Wright, C.W., Watjen, W. Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death. Phytochemistry 117, 237-244, 2015.

Runyoro, D.B., Joseph, C.C., Ngassapa, O.D., Darokar, M.P., Srivastava, S.K., Matee, M.I.N. and Wright, C.W. Anticandida agents from a Tanzanian plant, Albizia anthelmintica. Journal of the Chinese Chemical Society 62:669-674, 2015.

Gbedema, S.Y., Bayor, M.T., Annan, K., and Wright, C.W. Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection. Journal of Ethnopharmacology 169:176-182, 2015.

Sola, I., Artigas, A., Taylor, M.C., Gbedema, S.Y., Perez, B., Victoria Cloz, M. Wright, C.W., Kelly, J., Munoz-Torrero, D. Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. Bioorganic & Medicinal Chemistry Letters 24:5435-5438, 2014.

Olajide, O.O., Bhatia, H., A.C., de Oliveira, A.C.P., Wright, C.W. and Fiebich, B.L. Inhibition of neuroinflammation in LPS-activated microglia by cryptolepine. Evidence-Based Complementary and Alternative Medicine, Article ID 459723, 2013.

Ajaiyeoba, E.O., Abiodun, O.O., Ashidi, J.S., Houghton, P.J. and Wright, C.W. Cajachalcone: An antimalarial compound from Cajus cajan leaf extract. Journal of Parasitology Research 54:5188-5191, 2013.

Olajide, O.A., Bhatia, H.S., de Oliveira, C.P., Wright C.W. and Fiebich, B.L. Anti-neuroinflammatory properties of cryptolepine in human neuroblastoma cells: Possible involvement of NF-κB and p38MAPK inhibition. European Journal of Medicinal Chemistry, 63:333-339, 2013.

Kantamreddi, V.S.S. and Wright, C.W. Screening Indian plant species for antiplasmodial properties – ethnopharmacological compared to random selection. Phytotherapy Research, 2012.

Hazra, S., Ghosh, S., Debnath, S., Seville, S., Prajapati, V.K., Wright, C.W., Sundar, S., Hazra, B. Antileishmanial activity of cryptolepine analogues and apoptotic effects of 2,7-dibromocryptolepine against Leishmania donovani promastigotes. Parasitology Research, 111:195-203, 2012.

Stell, J.G.P., Wheelhouse, R.T. and Wright, C.W. Metabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase. Journal of Pharmacy and Pharmacology 64:237-243, 2012 15 Kantamreddi, V.S. and Wright, C.W. Complete NMR assignments of tubulosine. Natural Product Communications, 7:19-20, 2012.

Olajide, O., Heiss, E.H., Schachner, D., Wright, C.W., Vollmar, A.M. and Dirsch, V.M. Synthetic cryptolepine inhibits DNA binding of NF-κB. Bioorganic and Medicinal Chemistry 15:43-49, 2007

Watjen, W., Kulawik, A., Suckow-Schnitker, Chovolou, Y., Rohrig, R., Ruhl, S., Kampkotter, A., Addae-Kyereme, J., Wright, C.W. and Passreiter, C.M. Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation. Toxicology 242:71-79, 2007

Kantamreddi, V.S.S. and Wright, C.W. Investigation of Indian Diospyros species for antiplasmodial properties. eCAM (Electronic Complementary and Alternative Medicine), doi:10.1093/ecam/nem019, 2007

Seville, S., Phillips, R.M.,Shnyder,S.D.and Wright, C.W. Synthesis of cryptolepine analogues as potential bioreducible anticancer agents. Bioorganic and Medicinal Chemistry 15:6353-6360, 2007

Bayor, M.T., Ayim, J.S.K., Phillips, R.M.,Shnyder,S.D.and Wright, C.W. The evaluation of selected Ghanaian medicinal plants for cytotoxic activities. Journal of Science and Technology 27:16-22, 2007

Ajaiyeoba, E.O., Ashidi, J.S., Okpako, L.C., Houghton, P.J. and Wright, C.W. Antiplasmodial compounds from Cassia siamea stem bark extract. Phytotherapy Research, 22:254-255, 2008

Watjen, W., Suckow-Schnitker, A.K., Rohrig, R., Kulawik, A., Addae-Kyereme, J., Wright, C.W. and Passreiter, C.M. Prenylated flavonoid derivatives from the bark of Erythrina addisoniae. Journal of Natural Products 71:735-738, 2008

Lisgarten, J.N., Potter, B.S., Pitts, J.E. Palmer, R.A. and Wright, C.W. Structure of the antiplasmodial compound 7, 9-dinitrocryptolepine hydrochloride methanol solvate. Journal of Chemical Crystallography 38:807-813, 2008

Potter, B.S., Lisgarten, J.N., Pitts, J.E., Palmer, R.A. and Wright, C.W. X-ray crystallographic structure of the potent antiplasmodial compound 2,7-dibromocryptolepine acetic acid solvate. Journal of Chemical Crystallography 38:821-825, 2008

Bayor, M.T., Ayim, J.S.K., Marston, G., Phillips, R.M., Shnyder, S.D., Wheelhouse, R.T. and Wright, C.W. A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana. Natural Product Communications 3:1875-1878, 2008

Rojas, M., Wright, C.W., Pina, B., and Portugal, J. Genomewide expression profiling of the cryptolepine-induced toxicity in Saccharomyces cerevisiae. Antimicrobial Agents and Chemotherapy 52:3844-3850, 2008

Laryea, D., Isaksson, A., Wright, C.W., Larsson, R. and Nygren, P. Characterisation of the antitumour activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients. Investigational New Drugs 27:402-411, 2009

Oluwafemi, A.J., Okanla, O., Camps, P., Munoz-Torrero, D., Mackey, Z.B., Chiang, P.K., Seville, S. and Wright, C.W. Evaluation of cryptolepine and huperzine derivatives as lead compounds towards new agents for the treatment of human African Trypanosomiasis. Natural Product Communications, 4:193-198, 2009

Olajide, O. A., Ajayi, A.A. and Wright, C.W. Anti-inflammatory properties of cryptolepine. Phytotherapy Research, 23:1421-1425, 2009

Kantamreddi, V.S.S., Parida, S., Kommula, S.M. and Wright, C.W. Phytotherapy used in Orissa State, India, for treating malaria. Phytotherapy Research, 23:1638-1641, 2009

Maregesi, S., Van Miert, S., Pannecouque, C., Feiz-Haddad, M.H., Hermans, N., Wright, C.W., Vlietinck, A.J., Aspers, S. and Pieters, L. Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus. Planta Medica, 76:195-201, 2010

Wright, C.W., Linley, P.A., Brun, R., Wittlin, S. and Hsu, E. Ancient Chinese Methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalalarial activity. Molecules, 15:804-812, 2010

Prakasa Rao, T.S., Sarma, N.S., Murthy, Y.L.N., Kantamreddi, V.S.S.N., Wright, C.W. and Parameswaran, P.S. New polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley & Dendly). Tetrahedron Letters, 51:3583-3586, 2010

Defaux, J., Sala, M., Formosa, X., Galdeano, C. Taylor, M., Alobaid, W.A.A., Kelly, J.M., Wright, C.W., Camps, P., and Munoz-Torrero, D. Huprines as a new family of dual acting trypanocidal-antiplasmodial agents. Bioorganic and Medicinal Chemistry, 19:1702-1707, 2011

Sengupta, A., Chowdhury, S., Bose-Dasgupta, S., Wright, C.W., and Majumder, H.K. Cryptolepine-induced death of Leishmania donovani promastigotes is augmented by inhibition of authophagy. Molecular Biology International, Article ID 187850, 2011

Rasoanaivo, P., Wright, C.W., Willcox, M.L. and Gilbert, B. Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. Malaria Journal, 10 (Suppl 1):54, 2011

Hampson, H.C., Ho, C.Y., Palmer, R.A., Potter, B.S., Helliwell, M. and Wright, C.W. Low temperature X-ray crystallographic structure of the antiplasmodial compound 5-N-hydroxyethanequindoline hydrochloride 0.5CH3OH. Journal of Chemical Crystallography 41:1757-1762, 2011

Gopalan, R.C., Emerce, E., Wright, C.W., Karahalil, B., Karakaya, A.E. and Anderson, D. Effects of the antimalarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay. Toxicology Letters 207:322-325, 2011

Kantamreddi, V.S. and Wright, C.W. Complete NMR assignments of tubulosine. Natural Product Communications, 7:19-20, 2012

Stell, J.G.P., Wheelhouse, R.T. and Wright, C.W. Metabolism of cryptolepine and 2- fluorocryptolepine by aldehyde oxidase. Journal of Pharmacy and Pharmacology 64:237-243, 2012

Hazra, S., Ghosh, S., Debnath, S., Seville, S., Prajapati, V.K., Wright, C.W., Sundar, S., Hazra, B. Antileishmanial activity of cryptolepine analogues and apoptotic effects of 2,7-dibromocryptolepine against Leishmania donovani promastigotes. Parasitology Research, 111:195-203, 2012

Kantamreddi, V.S.S. and Wright, C.W. Screening Indian plant species for antiplasmodial properties – ethnopharmacological compared to random selection. Phytotherapy Research, 2012

Olajide, O.A., Bhatia, H.S., de Oliveira, C.P., Wright C.W. and Fiebich, B.L. Anti-neuroinflammatory properties of cryptolepine in human neuroblastoma cells: Possible involvement of NF-κB and p38MAPK inhibition. European Journal of Medicinal Chemistry, 63:333-339, 2013

Ajaiyeoba, E.O., Abiodun, O.O., Ashidi, J.S., Houghton, P.J. and Colin W. Wright. Cajachalcone: An antimalarial compound from Cajus cajan leaf extract. Journal of Parasitology Research 54:5188-5191, 2013

Olajide, O.O., Bhatia, H., A.C., de Oliveira, A.C.P., Wright, C.W. and Fiebich, B.L. Inhibition of neuroinflammation in LPS-activated microglia by cryptolepine. Evidence-Based Complementary and Alternative Medicine, Article ID 459723, 2013

Sola, I., Artigas, A., Taylor, M.C., Gbedema, S.Y., Perez, B., Victoria Cloz, M. Wright, C.W., Kelly, J., Munoz-Torrero, D. Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. Bioorganic & Medicinal Chemistry Letters 24:5435-5438, 2014

Gbedema, S.Y., Bayor, M.T., Annan, K., and Wright, C.W. Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection. Journal of Ethnopharmacology 169:176-182, 2015

Passreiter, C.M., Suckow-Schnitker, A-K., Kulawik, A., Addeae-Kyereme, J., Wright, C.W., Watjen, W. Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death. Phytochemistry 117, 237-244, 2015

Sola, I., Castella, Vianya, Galdeano, C., Taylor, M.C., Gbedema, S.Y., Perez, B., Clos, M.V. Jones, D.C., Fairlamb, A.H., Wright, C.W., Kelly, J.M. and Munoz-Torrero, D. Synthesis, biological profiling and mechanistic studies of 4-amonoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. Bioorganic and Medicinal Chemistry 23:5156-5167, 2015

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