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Professor Anant Paradkar

PositionProfessor of Pharmaceutical Engineering Science
LocationNorcroft Building (ex IPI), 3.17
DepartmentCentre for Pharmaceutical Engineering Science
RKT CentrePharmaceutical Engineering
Telephone+44 (0) 1274 233900
EmailA.Paradkar1@bradford.ac.uk
LinkedInVisit my LinkedIn profile

Research Interests (key words only)

Process and Product Innovation, Process Understanding, Hot Melt Extrusion, Transdermal Drug Delivery, Stabilised Amorphous Materials, Polymeric Microneedles, Liquid Crystalline Systems.

Teaching and Supervisory Responsibilities

Undergraduate:

  • MPharm: Pharmaceutics

Postgraduate:

  • MSc Pharmaceutical Technology
  • MEng Separation Processes Engineering

Administrative Responsibilities

Director: Centre for Pharmaceutical Engineering Science

Member:

  • Dean's Advisory Group , Faculty of Life Sciences
  • Research and Knowledge Committee, Faculty of Life Sciences
  • Institute of Life Sciences Research Board, Faculty of Life Sciences
  • Biomedical, Natural and Physical Sciences Research Ethics Panel

Biography

Professor Anant Paradkar holds an Interdisciplinary Chair in Pharmaceutical Engineering Science and is Director of the Centre for Pharmaceutical Engineering Science. He completed his PhD in Pharmaceutics and joined Bradford following a 20 year academic career in India. He has worked on various interdisciplinary collaborative research projects in the areas of process development and crystal and particle engineering, developing techniques such as crystallo-co-agglomeration, melt granulation, sono-crystallisation, spray drying of low Tg materials and liquid crystal precursors. He is currently working on the application of hot melt extrusion and sono-crystallisation to generate co-crystals and has been awarded a EPSRC funding and Yorkshire Enterprise Fellowship to strengthen exploitation and impact of this work.

In India, he received research funding from the All India Council for Technical Education, University Grants Commission, Department of Science and Technology and the Ministry of Defence. He has received an India-JSPS International Joint project on liquid crystalline systems, UK-India Education and Research Initiative (UKIERI) Fellowship and a Royal Society UK-India Science Network award He has supervised 10 PhD and 45 MPharm candidates and published over 90 research papers. Currently, he is supervising/ co-supervising  15 PhD students in various areas of research.

Awards and Recognition: 

  • 2010: Business Innovation Award, University of Bradford                                           
  • 2010: Finalist, Yorkshire Forward Innovator10 Award                                                 
  • 2009: Yorkshire Enterprise Fellowship                                                                           
  • 2009: Research and Knowledge Transfer Showcase Award for interdisciplinary research presentation
  • 2007: UK India Education and Research Initiative (UKIERI) Fellowship                     
  • 2006: Bharati Vidyapeeth Best Employee of the University
  • 2005: Indo-UK Science Network Scheme   (Royal Society and DST, India)                   
  • 2005: India-JSPS funded India-Japan Cooperation Programme (IJCP)                     
  • 2005: Young Pharmacy Teacher Award by Association of Pharmaceutical Teachers of India (APTI)

Study History

  • Bachelor of Pharmacy: Poona College of Pharmacy, University of Pune. India.
  • M. Pharm. (Pharmaceutics): Birla Institute of Technology, Ranchi, India
  • PhD: Nagpur University, Nagpur, India.

Professional History

  • 2010-present: Director, Centre for Pharmaceutical Engineering Science (CPES)
  • 2008-present: Professor and Interdisciplinary Chair in Pharmaceutical Engineering Science, University of Bradford, UK           
  • 1999-2008: Professor and Head, Department of Pharmaceutics, Bharati Vidyapeeth University, Pune, India
  • 1992-1999: Assistant Professor, Department of Pharmaceutics, Bharati Vidyapeeth University, Pune, India
  • 1988-1992: Lecturer, Department of Pharmaceutics, Nagpur College of Pharmacy, Nagpur, India

Professional Activities

Internal

  • Director of the  Centre for Pharmaceutical Engineering Science
  • Member,  Biomedical, Natural and Physical Sciences Research Ethics Panel

External

  • Member of The American Association of Pharmaceutical Scientists
  • Member of The Academy of Pharmaceutical Sciences
  • Member of The EUFEPS PAT Network

Research Areas

Process Development:  Currently my research focus is on non-infringing processing technologies for pharmaceuticals with special emphasis on Hot Melt Extrusion ( HME) and Ultrasound Assisted processing. Our interdisciplinary team has developed application of HME for co-crystallization. This solvent free continuous technology offers many advantages and easy for scale-up and commercialization. In process development we also focus on process optimization and characterization of process related properties like extensional rheology.

In this area our group has linkages with Professor Guo's group at Sichuan University, China and Dr. Kumarswamy and Dr. Suresh Bhat at National Chemical Laboratory, India.

    Technology Opportunity Solvent-Free Continuous Technology for Co-crystallization

Formulation Development: In the area of formulation development my focus is poorly soluble drug and nutraceutical molecules. Development of amorphous systems and liquid crystalline systems are adopted for different purposes.

The novel drug delivery concepts are also extended to molecules from natural products. We are developing nanoparticulate delivery systems for treatment of neurodegenerative conditions, cancers and endometriosis.

    METRC

Process Analytical Technology: The interdisciplinary group provides us with strong engineering expertise required for process analytics. Application of in-line measurement systems are being used to understand the mechanisms of novel products developed and process optimization.

Solid State Pharmaceutics:

  • Crystal and Particle Engineering: Green technologies for particle engineering including Extrusion, ultrasound and microwaves
  • Amorphous State Pharmaceuticals: Hot Melt Extrusion, Spray Drying especially low Tg drugs and stabilization using amphiphilic lipids

Molecular Pharmaceutics:

  • Rheological basis for process and formulation performance
  • Molecular aspects in biopharmaceutical performance of targeted systems
  • Molecular basis for stabilized amorphous systems
  • Role of extensional rheology in melt extrusion

Novel Drug Delivery Systems:

  • Polymeric controlled release systems. Major focus on transdermal drug delivery system
  • Microneedle and Magnetic Microarray Technologies for transdermal drug delivery
  • Liquid crystalline phases and their solid state precursors
  • Inhaled drug delivery systems
  • Moulded tablets, Porous polymer matrices
  • Nanoparticulate delivery systems

Phytopharmaceuticals and Nutraceuticals:

  • Applications of modern principles in design of extraction processes and delivery systems for phytochemicals and nutraceuticals

QbD and Process Analytical Technology (PAT):

  • In –line rheology, spectroscopy (NIR, Raman) and ultrasound transmission
  • Advanced statistical techniques: DoE, modelling, response surface methods
  • Computational and Predictive Pharmaceutics:  ANN, Neurofuzzy logic, Mesoscale simulations

Current Projects

  • A Novel Continuous Method for Co-crystal Formation, EPSRC (EP/J003360/1)
  • Development of Propolis Products, Technology Strategy Board KTP Scheme
  • Nanoparticulate Curcumin System with enhancers from Traditional Chinese Medicine (TCM) for treatment of Alzheimers, Changzhou People’s Hospital

Publications

  1. Ravindra Dhumal, Adrian Kelly, Phil Coates, Peter York, Anant Paradkar . 2010. Cocrystalization and simultaneous agglomeration using hot melt extrusion. Pharm. Res. 27, 2725-2733
  2. Rohit Mulik. Jukka Monkkonen, Risto Juvonen, Kakasaheb Mahadik, and Anant Paradkar. 2010. ApoE3 Mediated Poly(butyl) Cyanoacrylate Nanoparticles Containing Curcumin: Study of Enhanced Activity of Curcumin against Beta Amyloid Induced Cytotoxicity Using In Vitro Cell Culture Model. Molecular Pharmaceutics. Molecular Pharmaceutics, 7 (3),815¿825
  3. Suyog Aher, Ravindra S. Dhumal, Kakasaheb Mahadik, Anant R. Paradkar , Peter York. 2010. Ultrasound assisted cocrystallization from solution (USSC) containing a non-congruently soluble cocrystal component pair: Caffeine/maleic acid. Eur. J. Pharm. Sci. 41, 597-602
  4. Anant Paradkar, Adrian Kelly, Phil Coates and Peter York. 2009. Shear and extensional rheology of hydroxypropyl cellulose melt using capillary rheometry. Journal of Pharmaceutical and Biomedical Analysis; 49, 304-310.

    Anant Paradkar, Adrian Kelly, Phil Coates, Peter York. Method and Product.

    PCT/GB2009/050924; 27/07/2009
    WO/2010/013035; 04/02/2010

     

    • Sharvil Patil, E Venugopal, Suresh Bhat, K Mahadik, and Anant Paradkar, 2011Probing influence of mesophasic transformation on performance of self-emulsifying system: Effect of ion. Molecular Pharmaceutics,  Article in Press
    • Rohit Mulik. Jukka Monkkonen, Risto Juvonen, Kakasaheb Mahadik, and Anant Paradkar. 2010. ApoE3 Mediated Poly(butyl) Cyanoacrylate Nanoparticles Containing Curcumin: Study of Enhanced Activity of Curcumin against Beta Amyloid Induced Cytotoxicity Using In Vitro Cell Culture Model. Molecular Pharmaceutics; 7 (3),815-825
    • Anant Paradkar, Adrian Kelly, Phil Coates and Peter York. Shear and extensional rheology of hydroxypropyl cellulose melt using capillary rheometry. J  Pharm Biomed Analysis; 2009, 49,  304-310
    • Shailesh V. Biradar, Ravindra S. Dhumal, Anant R.. Paradkar. Rheological Investigation of Self-emulsification Process. J. Pharm. Sci. 2009, 12, 17-32.
    • Ravindra S. Dhumal, Shailesh V. Biradar, Anant R. Paradkar, Peter York. Particle engineering using sonocrystallization: Salbutamol Sulphate for Pulmonary delivery. Int. J. Pharm. 2009, 368, 129-137
    • Ravindra S. Dhumal, Shailesh V. Biradar, Siegeo Yamamura, Anant R. Paradkar, Peter York. Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability. Eur. J. Pharm. Biopharm. 2008, 70, 109-115.
    • Ravindra S. Dhumal, Shailesh V. Biradar, Anant R. Paradkar, Peter York. Ultrasound Assisted Engineering of Lactose Crystals. Pharm. Res. 2008,
    • Shamkant Shimpi, Kakasaheb Mahadik, Kanji Takada, Anant Paradkar. Application of polyclycolized glycerides in protection of amorphous form of etoricoxib during compression. Chem. Pharm. Bull. 2007, 55(10), 1448-1451
    • M. H. Shah, S. V. Biradar, A. R. Paradkar. Spray dried glyceryl monooleate-magnesium trisilicate dry powder as cubic phase precursor. Int J Pharm. 2006;323(1-2):18-26
    • Anant Paradkar, Manish Maheshwari, Ravindra N. Kamble, Ian Grimsey, Peter York. Design and evaluation of celecoxib porous particles using melt sonocrystallization. Pharm Res. 2006 ;23(6):1395-400.
    • Kaul N, Agrawal H, Paradkar AR, Mahadik KR. Effect of system variables involved in packed column SFC of nevirapine as model analyte using response surface methodology: application to retention thermodynamics, solute transfer kinetic study and binary diffusion coefficient determination. J Biochem Biophys Methods. 31;64(2):121-41, 2005
    • Anshuman A. Ambike, K. R. Mahadik, Anant Paradkar. Spray Dried Amorphous Solid Dispersions of Simvastatin; A Low Tg Drug: In vitro and In vivo Evaluations. Pharm. Res., 2005, 22, 990-998.
    • Shah MH, Paradkar A., Cubic liquid crystalline glyceryl monooleate matrices for oral delivery of enzyme. Int J Pharm. 2005, 294(1-2):161-71
    • S. S. Pisal, S. S. Kadam, A.R.Paradkar, K. R. Mahadik. Pluronic gels for nasal delivery of vitamin B12 ­: I Preformulation study. Int J Pharm, 270, 2004, 37-45

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