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Dr Rajendran C Gopalan

PositionLecturer in Pharmacology
LocationM30b Richmond Building
DepartmentSchool of Pharmacy
RKT CentrePharmaceutical Engineering
Telephone+44 (0) 1274 234771
EmailR.C.Gopalan@bradford.ac.uk

Research Interests (key words only)

In Vitro toxicology, wound healing, peristalsis

PhD Supervision

Shabana Akhtar: Biomarkers for reprotoxic and genotoxic effects after chemical exposure in humans

Teaching and Supervisory Responsibilities

Master of Pharmacy (MPharm):

  • Module Leader: Transport 1 (Stage 2, MPharm)
  • Module leader: Transport 2 (Stage 3, MPharm)
  • MPharm. Year 3 Projects

Biomedical Sciences (B.Sc.):

  • Human physiology 

Clinical Sciences (B.Sc.):

  • Endocrinology and Neurobiology ( PH 5114L) Stage 2
  • Common Diseases and their Treatment (PH8312D) Stage 3
  • CNS Mechanisms, Disorders and Therapeutics (CS-6004D) Stage 3

 

 

Administrative Responsibilities

  • Module coordinator: PH2228U and PH3311U
  • Admission panel committee
  • A panel member for approval of the following courses:
    • Master of Science in International Business management (Joint award with Universita Studi di Perugia, Italy) for the Faculty of Management & Law 3rd Feb 2016
    • BSc (Hons) Paramedic Studies in collaboration with Yorkshire Ambulance Service for the Faculty of Health Studies 16th and 17 February 2016

Biography

  • 2011- to present: Lecturer in Pharmacology
  • 2009 - January 2011Lecturer in Pharmacology (Part time)
  • 2008 - June 2009: Lecturer (part time), University of Bradford
  • 2007 to 2008: Lecturer in Physiology and Pharmacology, University of Bradford
  • 2006 to 2007: Post doctoral Researcher, Project Funded by Yorkshire forward
  • 2004 to 2005: Visiting Researcher,  University of Bradford

Study History

  • B.Sc. University of Mumbai, India
  • M.Sc. (Specialisation :Physiology) University of Mumbai, India
  • Ph.D. University of Mumbai, India
  • PGCHEP University of Bradford, UK

Professional Activities

  • Fellow of Higher Education Academy
  • Member United Kingdom Mutagen Society

Research Areas

Currently involved in supervising a PhD student researching in the area of toxicology of nanomaterials.

I am also interested in the area of wound healing and the effect of  pharmacological agents on peristalsis.

Current Projects

2012-2014: Effect of Nanomaterials in Mammalian Systems funded by UKIERI (British council)  

Nanomaterial technology has potential application in various fields including human health. Manufacture of nanomaterials of various shapes and compositions has increased sharply over the recent years.

Gold and silver nanoparticles are explored for diagnostic and therapeutic applications, metal oxides are widely used in sunscreens, coatings, paints or as catalysts. Nanoparticles of Co, Ni and Fe are magnetic in nature and have applications as magnetic resonance enhancers, for hyperthermia treatment etc.

Exposure of humans to these materials is inevitable due to their increasing use in biological applications as well as in electronics and catalysis. Exposure of humans to nanomaterials is possible from the stage of manufacture to release in the environment. Information is needed to assess their persistence in biological systems, a property that regulates accumulation of these particles to levels that may produce adverse health effects following long-term exposures to low concentrations. Also, the safety aspect of this technology has to be looked into in relation to health / environmental problems since its impact in humans and the environment is unknown.

The project aims at investigating some of these aspects

(Completed in December 2014)

Research Collaborations

  •  "Effect of Nanomaterials in Mammalian Systems" involves collaboration with Indian Institute of Toxicology (CSIR) Lucknow India (Completed in December 2014)

Publications

Effect of Drinking Water Disinfection By-Products in Human Peripheral Blood Lymphocytes and Sperm.  Aftab Ali, Malgorzata Kurzawa-Zegota, Mojgan Najafzadeh, Rajendran C Gopalan, Michael J Plewa, Diana Anderson.  Mutation Research:Fundamental and Molecular Mechanisms of Mutagenesis. 08/2014 (Impact factor 4.440)DOI: 10.1016/j.mrfmmm.2014.08.003)

Sensitivity and Specificity of the Empirical Lymphocyte Genome Sensitivity (LGS) Assay: Implications for Improving Cancer Diagnostics: Diana Anderson, Mojgan Najafzadeh, Rajendran Gopalan, Nader Ghaderi, Andrew J Scally, Stephen T Britland, Badie K Jacobs, P Dominic Reynolds, Justin Davies, Andrew L Wright, Shariff Al-Ghazal, David Sharpe, Morgan C Denyer . FASEB Journal 07/2014 (Impact factor 5.480) FASEB J fj.14-254748; published ahead of print July 25, 2014, doi:10.1096/fj.14-254748

In vitro sensitivities to UVA of lymphocytes from patients with colon and melanoma cancers and precancerous states in the micronucleus and the Comet assays

Mojgan NajafzadehAdolf BaumgartnerRajendran GopalanJustin B DaviesAndrew WrightP Dominic ReynoldsDiana Anderson

Mutagenesis  12/2011; DOI: 10.1093/mutage/ger087

Effects of the anti-malarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay

Rajendran C GopalanEsra EmerceColin W WrightBensu KarahalilAli E Karakaya,Diana Anderson

Toxicology letters 09/2011; DOI: 10.1016/j.toxlet.2011.09.010

"The effect of zinc oxide and titanium dioxide nanoparticles in the Comet assay with UVA photoactivation of human sperm and lymphocytes"

Rajendran C. Gopalan;  Ilham F. Osman;  Amir Amani;  Marcel De Matas; Diana Anderson  Nanotoxicology, Volume 3, Issue 1, 2009 , pages 33 - 39 .

Techniques for cryopreservation of intestinal smooth muscle cells.

Samira Lobo, Morgan Denyer, Rajendran C Gopalan and Farida javid.  Cryobiology 57(2008): 186 -189.

Patent: UV sensitivity Assay, UK patent No. 0621272.4, 2007.

Morgan Denyer, Stephen Britland, David Sharpe, Diana Anderson, Rajendran C Gopalan and University of Bradford.

Effects of Sex Hormones and their modulators on DNA damage in skin cells measured in the Comet assay.

Rajendran C Gopalan, Louisa D Nelson, Julie M Thornton, Diana  Anderson (2006). The Journal of Preventive Medicine; 14(1-2): 14-31.

Impact

I am currently a member of the National group formed to agree upon and develop a computer application for the common top hundred drugs to inform the students registered on the MPharm programme across UK. I have attended the first meeting at the Royal College of Physicians, Euston London on 9th Dec, 2015.

I was part of the University team that was one of the only three finalists in the Medical Devices and Diagnostics category, for the simple blood test developed to detect individuals with cancer at the eleventh annual Medipex Innovation Awards and Showcase October 8, 2015, organised by Medipex Ltd, the innovation hub for NHS organisations in Yorkshire and the Humber and the East Midlands.

Public/Academic/Stakeholder Engagement

Involved in Aim Higher and Master classes organised for students from the schools in the surrounding area.

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