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Dr Sonia Correa

PositionReader in Pharmacology
Location2.17 Norcroft building
DepartmentBradford School of Pharmacy
Telephone+44 (0) 1274 234695
EmailS.A.L.Correa@bradford.ac.uk

Research Interests (key words only)

Ageing of the brain; Learning and memory; Neurodegenerative diseases; Therapeutics targets; Synaptic plasticity; Trafficking of transmembrane receptors

Teaching and Supervisory Responsibilities

  • Biological communication –First year/FS1-Unit 5
  • Immunity and Infection-First year/FS1-Unit 7
  • NMR1-Second year/Unit 2 and 3

Administrative Responsibilities

  • Member of the School of Pharmacy Research Committee
  • Organise School of Pharmacy Seminars

Study History

  • Graduate in Physics from University of São Paulo, Brazil
  • PhD in Neurophysiology from the University of São Paulo, Brazil

Professional History

  • Research Fellow at the School of Life Sciences, University of Manchester
  • Research Associate at the MRC Centre for Synaptic Plasticity, University of Bristol
  • Senior Research Fellow at the School of Life Sciences, University of Warwick

Research Areas

The research in my lab is focuses on understanding the molecular mechanisms regulating modulations in glutamatergic synaptic transmission in the hippocampus. Long-term modulation in synaptic transmission, also termed synaptic plasticity, is thought to provide the molecular substrate that underlies learning and memory formation. We use a wide range of techniques including molecular and cell biology, biochemistry, immunocytochemistry combined with confocal imaging and electrophysiological recordings to study the mechanisms regulating endocytosis of glutamate receptors during synaptic plasticity.

Understanding the molecular mechanisms underlying modulation in synaptic transmission has become very timely, as it will provide insights into normal and abnormal functioning of the brain and may find novel therapeutic targets to slow cognitive decline associated with ageing and neurodegenerative diseases.

Current Projects

Real-time imaging of molecular mechanisms underlying synaptic dysfunction and neurodegeneration in Alzheimer's disease (Alzheimer’s Research UK equipment grant 2016)

Research Collaborations

Dr Jürgen Müller from Warwick Medical School

I have an on-going collaboration with Dr Müller to investigate:

  • the functional role of the MAPK scaffold protein KSR1 in synaptic plasticity using dissociated hippocampal neurons.
  • the cellular signalling pathways regulating vasopressin synthesis in the hypothalamus.

Dr Luis da Silva from University of São Paulo, Brazil

I have a well-established collaboration with Dr daSilva from the University of São Paulo to look at the molecular mechanisms by which activity-dependent gene transcription and protein synthesis regulates the endocytic machinery during synaptic plasticity in the hippocampus. Our collaboration has been funded by the bilateral BBSRC/FAPESP funding scheme.

Molecular mechanisms underlying learning and memory during the ageing process - talk at University of Southampton

Publications

Papers

  • Eales KL, Palygin O, O’Loughlin T, Rasooli-Nejad S, Gaestel M, Müller J, Collins DR, Pankratov Y and Corrêa SAL. (2014) The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. Nat. Commun., 5:4701 doi:1038/ncomms5701
  • Mabb AM, Je HS, Wall MJ, Robinson CG, Larsen RS, Qiang Y, Corrêa SAL, Ehlers MD (2014) Triad3A Regulates Synaptic Strength by Ubiquitination of Arc. Neuron, 82(6):1299-1316
  • Corrêa SAL, Hunter CJ, Palygin O, Wauters S, Martin KJ, Mackenzie C, McKelvey K, Morris RGM, Pankratov Y, Arthur JSC, Frenguelli BG (2012) MSK1 regulates homeostatic and experience-dependent synaptic plasticity. J Neurosci., 32(38):13039-13051
  • Canal F, Palygin O, Pankratov Y, Corrêa, SAL, Müller J. (2011) Feedback regulation of the MAP kinase scafold protein KSR1 regulates synaptic plasticity in hippocampal neurons. FASEB J 25(7):2362-72
  • Baines, AE, Corrêa, SAL, Irving AJ, Frenguelli BG (2011) Differential trafficking of adenosine receptors in hippocampal neurons monitored using GFP- and super ecliptic pHluorin-tagged receptor. Neuropharmacology 61:1-11
  • Appleby, VJ, Corrêa, SAL, Duckworth JK, Nash, JE, Noel J, Fitzjohn SM, Collingridge, GL, Molnar E (2011) LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression. J Neurochem, 116(4):530-43
  • Nash, JE, Appleby VJ, Corrêa SAL, Wu H, Garner CC, Fitzjohn SM, Collingridge, GL, Molnar E (2010) Disruption of the interaction between myosin VI and SAP97 is associated with a reduction in the number of AMPARs at hippocampal synapses. J Neurochem, 112(3):677-90
  • Corrêa SAL, Müller J., Collingridge, GL Marrion, NV. (2009) Rapid endocytosis provides restricted somatic expression of a potassium channel in central neurons. J Cell Sci., 122:4186-4194
  • Kantamneni, S, Holman, D, Wilkinson KA, Corrêa SAL, Feligioni M, Odgen S, Fraser W, Nishimune, A, Henley JM (2008) GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation. J Neurochem, 107(1):86-95
  • Moult PR, Corrêa SAL, Collingridge GL, Fitzjohn SM, Bashir ZI (2008) Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase: a novel signalling mechanism underlying synaptically induced metabotropic glutamate receptor-dependent long-term depression in the hippocampus. J. Physiology, 15; 586(10): 2499-510

Reviews and book chapters

  • Corrêa SAL and Eales KL (2012) The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease, Journal of Signal Transduction, Vol 2012, Article ID 649079, 12 pages
  • Frenguelli BG and SAL Corrêa (2012) Regulation and role of MSK in the mammalian brain. Molecular Biology Intelligence Unit Landes Bioscience, Austin, Texas USA

 

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