Prof Vladimir Botchkarev was delighted to receive an award confirmation letter for grant application to the MRC.More details »
Published: Tuesday 28th June 2016
Dr Miriam Wittmann, Dr Natasha Botchkareva, Dr Martin Stacey and Dr Ed Vital receive grant from the charity LUPUS UKMore details »
Published: 9 November 2015
Dr Andrei Mardaryev has won a prestigious young investigator award from the MRC.More details »
Dr Natasha Botchkareva's research on the role of micro RNAs in hair biology has extended to Alopecia Areata.More details »
The Centre for Skin Sciences awarded grant (£215K) by industry funder to explore new insights into healthy hairMore details »
Published: 1 March 2015
MRC NSFC grant (£500K), one of only 5 grants made, was awarded to Professor Vladimir Botchkarev and Professor Guoliang Xu (Shanghai Institute of Biological Sciences)More details »
INDUSTRIAL RESEARCH GRANT AWARDED TO PROF DES TOBIN (£237,750; April 2014-March 2016)
Prof Des Tobin has been awarded an industrial research grant to fund a 2 year post doctoral research assistant on a project to explore factors involved in the regulation of melanin processing in human skin. Better understanding of these mechanisms should lead to novel treatments for hyper-pigmentation conditions like aging-associated solar lentigo, and hormone-associated melasma etc. It will involve investigating at the cell biological, molecular biological and biochemical levels how melanin is normally processed in human epidermis and how this may become disrupted by aging and in curtained clinically-relevant conditions like melasma.
EUROPEAN INDUSTRIAL DOCTORAL TRAINING GRANT AWARDED TO CSS (€795,031; Oct 2013 - Sept 2017)
Five members of the Centre for Skin Sciences (Botchkareva, Tobin, Thornton, Botchkarev and Mardaryev) have been jointly awarded an EU Grant with colleagues in Philips Electronics Nederland BV. Project 'CLaSSiC' is an interdisciplinary cross-sector research project focused on Light Therapy in skin and includes studies that range from fundamental understanding of skin stem cell interaction with light at a molecular level; development of tissue models in which to explore functional biophysics; optical modelling and experimental biomedical optics, all culminating in product design. Three Early Stage Researchers will work together on "CLaSSiC both at Bradford, centre for Skin Sciences and Philips, Nederlands.
MRC RESEARCH GRANT AWARDED TO DR NATALIA BOTCHKAREVA £354,405; APRIL 2013 - MARCH 2016)
Dr Natalia Botchkareva is awarded a MRC grant to study the Role of microRNA-214 in the control of skin regeneration. Dr Botchkareva and Post-Doctoral Research Assistant Dr. Eerik Aunin will address novel mechanisms of skin regeneration during normal development and when induced by injury. Recent data has demonstrated that activities of many cellular signalling pathways controlling skin development and its postnatal regeneration are governed by microRNAs (miRNAs), which negatively regulate gene expression. This project will look at how one of those miRNAs, namely miR-214, impacts skin regeneration during normal development and when induced by injury. The knowledge gained from this study will also provide new opportunities for the development of novel microRNA-based therapies to treat aberrant tissue growth and regenerative conditions.
BBSRC RESEARCH GRANT AWARDED TO PROF VLADIMIR BOTCHKAREV and DR YONGHONG PENG (£412,889; JULY 2013 - JUNE 2016)
Professor Vladimir Botchkarev (Principal Investigator) and Dr. Yonghong Peng (Co-Investigator) are awarded a BBSRC grant to study the Role of Satb1 in the control of topological genome organization during skin development and ageing. The grant has a life of three years and Prof Botchkarev is working with Post-Doctoral Research Assistant Dr. Jana Rudolf to address novel mechanisms that control higher-order chromatin remodelling in skin epithelial cells during development and ageing.
BRITISH SKIN FOUNDATION GRANT AWARDED TO DR MIRIAM WITTMANN (£81,000; Dec 2012 to Dec 2015)
Dr Miriam Wittmann has been awarded a grant for a three year project entitled "What activates IL-36 in vivo? Investigating the importance of IL-36 in psoriatic inflammation". Dr Wittmann is the PI for the project which is be based at the University of Leeds.
IL-36 is highly expressed in lesional psoriasis and cultured psoriatic keratinocytes show a dramatic IL-36 upregulation in response to cytokine stimulation. Recent evidence suggests that IL-36 is a significant amplifier of psoriatic inflammation as it acts synergistically with TNF and IL-17 on neutrophil attraction. Importantly, these latter mediators are the main inducers of IL-36 expression thus placing it in the centre of a positive amplification loop. Our preliminary findings suggest that only processed versions of IL-36 show high biologic activity on primary skin cells. However, the processed forms of IL-36 have so far not been demonstrated in vivo. It is unclear if and how IL-36 is released and cleaved in inflamed skin. The functional response to IL-36 is determined by expression of the two receptors chains and by the endogenous receptor antagonist IL-36RA. Three independent studies have now shown that pustular psoriasis is associated with loss-of-function mutations of IL-36RA. In this project we aim to investigate the in vivo presence of processed IL-36 and analyse in vitro, which human proteases, present in the inflamed skin compartment, cleave this emerging mediator for psoriatic inflammation. In addition, analysis on the presence, regulation and functional activity of IL-6RA will give us valuable information about its role in diseased skin. The findings of this study into the IL-36 axis could form the basis for the development of new treatment approaches such as topical (specific) protease inhibitors or agents acting on the upregulation of endogenous IL-36RA.