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Prof Vladimir Botchkarev receives MRC/Newton Fund Grant

Published: 1 March 2015
Prof Vladimir Botchkarev receives MRC/Newton Fund Grant

MRC NSFC grant (£500K), one of only 5 grants made, was awarded to Professor Vladimir Botchkarev and Professor Guoliang Xu (Shanghai Institute of Biological Sciences)

Following very successful NSFC – MRC Stem Cell Research Workshop held in Shanghai, Professor Botchkarev together with collaborators in China and Co PIs Drs Mike Fessing, Yong Hong Peng and Krzysztof Poterlowicz made a successful bid to build strong collaborative bridge to China in this MRC grant which is supported by the Newton fund, designed to facilitate UK academic links with top scientists in emerging countries.

Epigenetic mechanisms play an important role in the control of stem cell activity during development and regeneration. Understanding on how and why these mechanisms are altered in many disorders (cancer, autoimmune diseases, ageing, etc.) has become a growing priority in biomedical research. This project represents a logical continuation of an existing collaboration between two laboratories funded by the grants from the MRC and NSFC, which focused on the analyses of roles of distinct epigenetic regulators in the control of stem cell activity during development and regeneration. This project focuses on the role of Polycomb gene Cbx4 in the control of stem cell activity during skin development and wound-induced skin regeneration. The hypothesis of the project is that Cbx4 plays important roles in the control of gene expression programmes in epithelial stem cells during skin development and wound-induced skin regeneration.

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