Professor Anant Paradkar,Professor of Pharmaceutical Engineering
Information about Professor Anant Paradkar at the University of Bradford.
- School of Pharmacy & Medical Sciences
(Faculty of Life Sciences) - Email:
- a.paradkar1@bradford.ac.uk
- Telephone:
- +44 1274 233900
Biography
Professor Anant Paradkar holds an Interdisciplinary Chair in Pharmaceutical Engineering Science and is Director of the Centre for Pharmaceutical Engineering Science. He completed his PhD in Pharmaceutics and joined Bradford following a 20 year academic career in India. He has worked on various interdisciplinary collaborative research projects in the areas of process development and crystal and particle engineering, developing techniques such as crystallo-co-agglomeration, melt granulation, sono-crystallisation, spray drying of low Tg materials and liquid crystal precursors. He is currently working on the application of hot melt extrusion and sono-crystallisation to generate co-crystals and has been awarded a EPSRC funding and Yorkshire Enterprise Fellowship to strengthen exploitation and impact of this work.In India, he received research funding from the All India Council for Technical Education, University Grants Commission, Department of Science and Technology and the Ministry of Defence. He has received an India-JSPS International Joint project on liquid crystalline systems, UK-India Education and Research Initiative (UKIERI) Fellowship and a Royal Society UK-India Science Network award He has supervised 10 PhD and 45 MPharm candidates and published over 90 research papers. Currently, he is supervising/ co-supervising 15 PhD students in various areas of research.Awards and Recognition: 2010: Business Innovation Award, University of Bradford 2010: Finalist, Yorkshire Forward Innovator10 Award 2009: Yorkshire Enterprise Fellowship 2009: Research and Knowledge Transfer Showcase Award for interdisciplinary research presentation2007: UK India Education and Research Initiative (UKIERI) Fellowship 2006: Bharati Vidyapeeth Best Employee of the University2005: Indo-UK Science Network Scheme (Royal Society and DST, India) 2005: India-JSPS funded India-Japan Cooperation Programme (IJCP) 2005: Young Pharmacy Teacher Award by Association of Pharmaceutical Teachers of India (APTI)Professor Anant Paradkar holds an Interdisciplinary Chair in Pharmaceutical Engineering Science and is Director of the Centre for Pharmaceutical Engineering Science. He completed his PhD in Pharmaceutics and joined Bradford following a 20 year academic career in India. He has worked on various interdisciplinary collaborative research projects in the areas of process development and crystal and particle engineering, developing techniques such as crystallo-co-agglomeration, melt granulation, sono-crystallisation, spray drying of low Tg materials and liquid crystal precursors. He is currently working on the application of hot melt extrusion and sono-crystallisation to generate co-crystals and has been awarded a EPSRC funding and Yorkshire Enterprise Fellowship to strengthen exploitation and impact of this work.In India, he received research funding from the All India Council for Technical Education, University Grants Commission, Department of Science and Technology and the Ministry of Defence. He has received an India-JSPS International Joint project on liquid crystalline systems, UK-India Education and Research Initiative (UKIERI) Fellowship and a Royal Society UK-India Science Network award He has supervised 10 PhD and 45 MPharm candidates and published over 90 research papers. Currently, he is supervising/ co-supervising 15 PhD students in various areas of research.Awards and Recognition: 2010: Business Innovation Award, University of Bradford 2010: Finalist, Yorkshire Forward Innovator10 Award 2009: Yorkshire Enterprise Fellowship 2009: Research and Knowledge Transfer Showcase Award for interdisciplinary research presentation2007: UK India Education and Research Initiative (UKIERI) Fellowship 2006: Bharati Vidyapeeth Best Employee of the University2005: Indo-UK Science Network Scheme (Royal Society and DST, India) 2005: India-JSPS funded India-Japan Cooperation Programme (IJCP) 2005: Young Pharmacy Teacher Award by Association of Pharmaceutical Teachers of India (APTI)
Research
Process Development: Currently my research focus is on non-infringing processing technologies for pharmaceuticals with special emphasis on Hot Melt Extrusion ( HME) and Ultrasound Assisted processing. Our interdisciplinary team has developed application of HME for co-crystallization. This solvent free continuous technology offers many advantages and easy for scale-up and commercialization. In process development we also focus on process optimization and characterization of process related properties like extensional rheology.In this area our group has linkages with Professor Guos group at Sichuan University, China and Dr. Kumarswamy and Dr. Suresh Bhat at National Chemical Laboratory, India. Technology Opportunity Solvent-Free Continuous Technology for Co-crystallizationFormulation Development: In the area of formulation development my focus is poorly soluble drug and nutraceutical molecules. Development of amorphous systems and liquid crystalline systems are adopted for different purposes.The novel drug delivery concepts are also extended to molecules from natural products. We are developing nanoparticulate delivery systems for treatment of neurodegenerative conditions, cancers and endometriosis. METRCProcess Analytical Technology: The interdisciplinary group provides us with strong engineering expertise required for process analytics. Application of in-line measurement systems are being used to understand the mechanisms of novel products developed and process optimization.Solid State Pharmaceutics:Crystal and Particle Engineering: Green technologies for particle engineering including Extrusion, ultrasound and microwavesAmorphous State Pharmaceuticals: Hot Melt Extrusion, Spray Drying especially low Tg drugs and stabilization using amphiphilic lipidsMolecular Pharmaceutics:Rheological basis for process and formulation performanceMolecular aspects in biopharmaceutical performance of targeted systemsMolecular basis for stabilized amorphous systemsRole of extensional rheology in melt extrusionNovel Drug Delivery Systems:Polymeric controlled release systems. Major focus on transdermal drug delivery systemMicroneedle and Magnetic Microarray Technologies for transdermal drug deliveryLiquid crystalline phases and their solid state precursorsInhaled drug delivery systemsMoulded tablets, Porous polymer matricesNanoparticulate delivery systemsPhytopharmaceuticals and Nutraceuticals:Applications of modern principles in design of extraction processes and delivery systems for phytochemicals and nutraceuticalsQbD and Process Analytical Technology (PAT):In âline rheology, spectroscopy (NIR, Raman) and ultrasound transmissionAdvanced statistical techniques: DoE, modelling, response surface methodsComputational and Predictive Pharmaceutics: ANN, Neurofuzzy logic, Mesoscale simulationsProcess Development: Currently my research focus is on non-infringing processing technologies for pharmaceuticals with special emphasis on Hot Melt Extrusion ( HME) and Ultrasound Assisted processing. Our interdisciplinary team has developed application of HME for co-crystallization. This solvent free continuous technology offers many advantages and easy for scale-up and commercialization. In process development we also focus on process optimization and characterization of process related properties like extensional rheology.In this area our group has linkages with Professor Guos group at Sichuan University, China and Dr. Kumarswamy and Dr. Suresh Bhat at National Chemical Laboratory, India. Technology Opportunity Solvent-Free Continuous Technology for Co-crystallizationFormulation Development: In the area of formulation development my focus is poorly soluble drug and nutraceutical molecules. Development of amorphous systems and liquid crystalline systems are adopted for different purposes.The novel drug delivery concepts are also extended to molecules from natural products. We are developing nanoparticCurrent ProjectsA Novel Continuous Method for Co-crystal Formation, EPSRC (EP/J003360/1)Development of Propolis Products, Technology Strategy Board KTP SchemeNanoparticulate Curcumin System with enhancers from Traditional Chinese Medicine (TCM) for treatment of Alzheimers, Changzhou Peopleâs Hospital
Publications
There are 98 publications involving or that are attributed to Professor Anant Paradkar. They are listed as:
- book chapter (4)
- peer reviewed journal (94)
Book Chapter
Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
---|---|---|---|---|---|---|---|---|---|---|---|
Impact of the Polymorphic Form of Drugs/NCEs on Preformulation and Formulation Development | 2019 | Innovative Dosage Forms: Design and Development at Early Stage | Innovative Dosage Forms: Design and Development at Early Stage | MHD Bashir Alsirawan, Anant Paradkar | Yogeshwar Bachhav | Wiley‐VCH | https://doi.org/10.1002/9783527812172.ch1 | ||||
Aerosols in pharmaceutical product development | 2019 | Drug Delivery Systems | Drug Delivery Systems | 521 - 577 | Deb P.K.;Abed S.N.;Maher H.;Al-Aboudi A.;Paradkar A.;Bandopadhyay S.;Tekade R.K. | 9780128144879 | 10.1016/B978-0-12-814487-9.00011-9 | ||||
Pharmaceutical and biomedical applications of polymers | 2018 | Basic Fundamentals of Drug Delivery | Basic Fundamentals of Drug Delivery | 203 - 267 | Deb P.K.;Kokaz S.F.;Abed S.N.;Paradkar A.;Tekade R.K. | 9780128179109 | 10.1016/B978-0-12-817909-3.00006-6 | ||||
Protein/peptide drug delivery systems: Practical considerations in pharmaceutical product development | 2018 | Basic Fundamentals of Drug Delivery | Basic Fundamentals of Drug Delivery | 651 - 684 | Deb P.K.;Al-Attraqchi O.;Chandrasekaran B.;Paradkar A.;Tekade R.K. | 9780128179109 | 10.1016/B978-0-12-817909-3.00016-9 |
Peer Reviewed Journal
Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
---|---|---|---|---|---|---|---|---|---|---|---|
Microwave assisted synthesis of caffeine/maleic acid co-crystals: The role of the dielectric and physicochemical properties of the solvent | 2013 | CrystEngComm | 15 | 3705 - 3710 | Pagire S.;Korde S.;Ambardekar R.;Deshmukh S.;Dash R.;Dhumal R.;Paradkar A. | 1466-8033 | 10.1039/c3ce40292d | ||||
Ultrasound-assisted preparation of novel ibuprofen-loaded excipient with improved compression and dissolution properties | 2016 | Drug Development and Industrial Pharmacy | 42 | 1553 - 1563 | Gandhi P.;Patil S.;Aher S.;Paradkar A. | 0363-9045 | 10.3109/03639045.2016.1151035 | ||||
Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug | 2018 | Drug Development and Industrial Pharmacy | 44 | 206 - 214 | Kulkarni C.;Kelly A.;Gough T.;Jadhav V.;Singh K.;Paradkar A. | 0363-9045 | 10.1080/03639045.2017.1386200 | ||||
In-process rheometry as a PAT tool for hot melt extrusion | 2018 | Drug Development and Industrial Pharmacy | 44 | Kelly, A.; Gough, T.; Isreb, M.; Dhumal, R. S.; Jones, J. W.; Nicholson, S.; Dennis, A. B.; Paradkar, A. | https://doi.org/10.1080/03639045.2017.1408641 | ||||||
Aqueous and pH Dependent Coacervation Method for Taste Masking of Paracetamol via Amorphous Solid Dispersion Formation | 2021 | Scientific Reports | xx | Basheer Al-kasmi, M. Bashir Alsirawan, Anant Paradkar, Abdulhakim Nattouf, and Hind El-zein | Nature | ||||||
Enhancement of hepatoprotective efficacy of propolis by fabrication of liposomes, as a platform nano-formulation for multi-component natural medicine | 2012 | Current Drug Delivery | 9 | 477 - 486 | Ambardekar R.;Mahadik K.;Paradkar A.;Harsulkar A. | 1567-2018 | 10.2174/156720112802650653 | ||||
Development and validation of a densitometric HPTLC method for simultaneous analysis of wedelolactone and asiaticoside in a polyherbal formulation | 2010 | Acta Chromatographica | 22 | 651 - 663 | Sathiyanarayanan L.;Paradkar A.;Mahadik K. | 1233-2356 | 10.1556/AChrom.22.2010.4.13 | ||||
Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability | 2008 | European Journal of Pharmaceutics and Biopharmaceutics | 70 | 109 - 115 | Dhumal R.;Biradar S.;Yamamura S.;Paradkar A.;York P. | 0939-6411 | 10.1016/j.ejpb.2008.04.001 | ||||
In situ monitoring of competitive coformer exchange reaction by 1H MAS Solid-state NMR | 2024 | Molecular Pharmaceutics | In Press | Chaithanya Hareendran, Bashir Alsirawan, Anant Paradkar, and T.G. Ajithkumar | American Chemical Society | https://pubs.acs.org/doi/epdf/10.1021/acs.molpharmaceut.3c01118 | |||||
Design, synthesis and pharmacological evaluation of pyrimidobenzothiazole-3-carboxylate derivatives as selective L-type calcium channel blockers | 2015 | Bioorganic and Medicinal Chemistry | 23 | 6689 - 6713 | Chikhale R.;Thorat S.;Pant A.;Jadhav A.;Thatipamula K.;Bansode R.;Bhargavi G.;Karodia N.;Rajasekharan M.;Paradkar A.;Khedekar P. | 0968-0896 | 10.1016/j.bmc.2015.09.009 | ||||
Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in vitro anticancer activity by induction of apoptosis | 2010 | International Journal of Pharmaceutics | 398 | 190 - 203 | Mulik R.;Mönkkönen J.;Juvonen R.;Mahadik K.;Paradkar A. | 0378-5173 | 10.1016/j.ijpharm.2010.07.021 | ||||
Particle engineering using sonocrystallization: Salbutamol sulphate for pulmonary delivery | 2009 | International Journal of Pharmaceutics | 368 | 129 - 137 | Dhumal R.;Biradar S.;Paradkar A.;York P. | 0378-5173 | 10.1016/j.ijpharm.2008.10.006 | ||||
Development of stability-enhanced ternary solid dispersions via combinations of HPMCP and Soluplus®processed by hot melt extrusion | 2017 | International Journal of Pharmaceutics | 532 | 603 - 611 | Albadarin A.;Potter C.;Davis M.;Iqbal J.;Korde S.;Pagire S.;Paradkar A.;Walker G. | 0378-5173 | 10.1016/j.ijpharm.2017.09.035 | ||||
ApoE3 mediated polymeric nanoparticles containing curcumin: Apoptosis induced in vitro anticancer activity against neuroblastoma cells | 2012 | International Journal of Pharmaceutics | 437 | 29 - 41 | Mulik R.;Mönkkönen J.;Juvonen R.;Mahadik K.;Paradkar A. | 0378-5173 | 10.1016/j.ijpharm.2012.07.062 | ||||
Hot-melt extrusion process impact on polymer choice of glyburide solid dispersions: The effect of wettability and dissolution. | 2019 | International Journal of Pharmaceutics | 559 | Alshafiee M;Aljammal MK;Markl D;Ward A;Walton K;Blunt L;Korde S;Pagire SK;Kelly AL;Paradkar A;Conway BR;Asare-Addo K; | 1873-3476 | 10.1016/j.ijpharm.2019.01.038 | |||||
Injection Moulded Controlled Release Amorphous Solid Dispersions: Synchronized Drug and Polymer Release for Robust Performance. | 2020 | International Journal of Pharmaceutics | 575 | Deshmukh S;Paradkar A;Abrahmsén-Alami S;Govender R;Viridén A;Winge F;Matic H;Booth J;Kelly A; | 1873-3476 | 10.1016/j.ijpharm.2019.118908 | |||||
Improving Stability of Effervescent Products by Co-Crystal Formation: A Novel Application of Crystal Engineered Citric Acid | 2020 | Crystal Growth and Design | 20 | 4839 - 4844 | Pagire, SK; Seaton, CC; Paradkar, A | ACS | https://doi.org/10.1021/acs.cgd.0c00616 | ||||
Understanding Matrix Assisted Continuous Cocrystallisation using Data Mining approach in Quality by Design (QbD)* | 2020 | Crystal Growth and Design | 20 | Billy Chabalenge, Sachin Korde, Adrian L Kelly, Daniel Neagu and Anant Paradkar | ACS | https://doi.org/10.1021/acs.cgd.0c00338 | |||||
Solid-State Competitive Destabilization of Caffeine Malonic Acid cocrystal: Mechanistic and Kinetic Investigation | 2020 | Crystal Growth and Design | DOI: 10.1021/acs.cgd.0c01246 | M. Bashir Alsirawan, Xiaojun Lai, Rafel Prohens, Venu Vangala, Sudhir Pagire, Petro Shelley, Thomas Bannan, David Topping, and Anant Paradkar | American Chemical Society | DOI: 10.1021/acs.cgd.0c01246 | |||||
Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology | 2018 | Crystal Growth and Design | 18 | 2297 - 2304 | Korde, S.; Pagire, S.; Pan, H.; Seaton, C.; Kelly, A.; Chen, Y.; Wang, Q.; Coates, P.; Paradkar, A. | https://doi.org/10.1021/acs.cgd.7b01733 | |||||
Mapping ion-induced mesophasic transformation in lyotropic in situ gelling system and its correlation with pharmaceutical performance | 2013 | Pharmaceutical Research | 30 | 1906 - 1914 | Patil S.;Venugopal E.;Bhat S.;Mahadik K.;Paradkar A. | 0724-8741 | 10.1007/s11095-013-1033-4 | ||||
Cocrystalization and simultaneous agglomeration using hot melt extrusion | 2010 | Pharmaceutical Research | Paradkar, A.;Dhumal, R.S.;Kelly, A.L.;York, P.;Coates, P.D.; | 10.1007/s11095-010-0273-9 | |||||||
Adsorption studies of bromhexine hydrochloride on talc | 2013 | Research Journal of Pharmacy and Technology | 6 | 1247 - 1250 | Jadhav N.;Paradkar A.;Shah G. | 0974-360X | |||||
Shear and extensional rheology of hydroxypropyl cellulose melt using capillary rheometry | 2009 | Journal of Pharmaceutical and Biomedical Analysis | Paradkar, A.;Kelly, A.;Coates, P.;York, P.; | 10.1016/j.jpba.2008.11.014 | |||||||
Mechanism of Hydrogen-Bonded Complex Formation between Ibuprofen and Nanocrystalline Hydroxyapatite | 2017 | Langmuir | Ryabenkova, Y.;Jadav, N.;Conte, M.;Hippler, M.F.A.;Reeves-Mclaren, N.;Coates, P.D.;Twigg, P.;Paradkar, A.; | 10.1021/acs.langmuir.6b04510 | |||||||
Novel pepper extract for enhanced P-glycoprotein inhibition | 2009 | Journal of Pharmacy and Pharmacology | 61 | 1179 - 1186 | Aher S.;Biradar S.;Gopu C.;Paradkar A. | 0022-3573 | 10.1211/jpp.61.09.0007 | ||||
Cefuroxime axetil solid dispersion with polyglycolized glycerides for improved stability and bioavailability | 2009 | Journal of Pharmacy and Pharmacology | 61 | 743 - 751 | Dhumal R.;Biradar S.;Aher S.;Paradkar A. | 0022-3573 | 10.1211/jpp.61.06.0006 | ||||
Nootropic activity of lipid-based extract of Bacopa monniera Linn. compared with traditional preparation and extracts | 2009 | Journal of Pharmacy and Pharmacology | 61 | 1537 - 1544 | Lohidasan S.;Paradkar A.;Mahadik K. | 0022-3573 | 10.1211/jpp/61.11.0014 | ||||
Enhanced brain targeting of curcumin by intranasal administration of a thermosensitive poloxamer hydrogel | 2013 | Journal of Pharmacy and Pharmacology | 65 | 807 - 816 | Chen X.;Zhi F.;Jia X.;Zhang X.;Ambardekar R.;Meng Z.;Paradkar A.;Hu Y.;Yang Y. | 0022-3573 | 10.1111/jphp.12043 | ||||
Isolation, biochemical and genetic characterizations of alcohol-producing yeasts from the flowers of Woodfordia fruticosa | 2013 | Journal of Young Pharmacists | 5 | 191 - 194 | Manwar J.;Mahadik K.;Paradkar A.;Sathiyanarayanan L.;Vohra M.;Patil S. | 0975-1483 | 10.1016/j.jyp.2013.11.007 | ||||
Free radical scavenging and anti-inflammatory activity of Indian propolis | 2009 | Pharmacologyonline | 3 | 991 - 1002 | Ambardekar R.;Gilda S.;Mahadik K.;Harsulkar A.;Paradkar A. | 1827-8620 | |||||
In vivo and in vitro antioxidant activity of lipid based extract of Bacopa monniera Linn. compared to conventional extract and traditional preparation | 2010 | European Journal of Integrative Medicine | 2 | 93 - 101 | Sathiyanarayanan L.;Paradkar A.R.;Mahadik K.R. | 1876-3820 | 10.1016/j.eujim.2009.12.003 | ||||
Characterization of Cashew nut gum as a binder in tablet formulation | 2012 | Journal of International Pharmaceutical Research | 4 | 95 - 98 | Wairkar S.;Ambike A.;Paradkar A. | 0975-2366 | |||||
Preparation and evaluation of talc agglomerates obtained by wet spherical agglomeration as a substrate for coating | 2011 | Pharmaceutical Development and Technology | 16 | 152 - 161 | Jadhav N.;Pawar A.;Paradkar A. | 1083-7450 | 10.3109/10837450903544567 | ||||
Nicotinamide extrudates as novel anti-aging and collagen promoting platform: a comparative cosmeceutical study versus the gel form | 2020 | Pharmaceutical Development and Technology | Alyoussef A.;Nasr M.;Ahmed R.F.;Ahmed Farid O.A.H.;Bakeer R.;Karandikar H.;Paradkar A. | 1083-7450 | 10.1080/10837450.2020.1803908 | ||||||
Synthesis of caffeine/maleic acid co-crystal by ultrasound assisted slurry co-crystallization | 2017 | Journal of Pharmaceutical Sciences | 106 | Apshingekar, Prafulla P.; Aher, Suyog; Kelly, Adrian L.; Brown, Elaine C.; Paradkar, Anant R. | https://doi.org/10.1016/j.xphs.2016.09.009 | ||||||
Professor Peter York—A Distinguished Career in Powders, Processing, and Particle Design | 2017 | Journal of Pharmaceutical Sciences | 106 | 2 - 4 | Taylor L.;Rantanen J.;Paradkar A.;Kawashima Y.;Zhang J. | 0022-3549 | 10.1016/j.xphs.2016.09.006 | ||||
Rheological investigation of self-emulsification process: Effect of co-surfactant | 2009 | Journal of Pharmacy and Pharmaceutical Sciences | 12 | 164 - 174 | Biradar S.;Dhumal R.;Paradkar A. | 1482-1826 | |||||
Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study | 2011 | Journal of Indian Society of Periodontology | 15 | 35 - 38 | Behal R.;Mali A.;Gilda S.;Paradkar A. | 0972-124X | 10.4103/0972-124X.82264 | ||||
Effect of Ultrasound on Molecular Structure Development of Polylactide | 2014 | Polymer - Plastics Technology and Engineering | Bao, W.;Wu, H.;Guo, S.;Paradkar, A.;Kelly, A.;Brown, E.;Coates, P.; | 10.1080/03602559.2014.886062 | |||||||
Design, synthesis, pharmacological evaluation and molecular docking studies of substituted oxadiazolyl-2-oxoindolinylidene propane hydrazide derivatives | 2016 | Journal of the Brazilian Chemical Society | 27 | 1998 - 2010 | Kerzare D.;Chikhale R.;Bansode R.;Amnerkar N.;Karodia N.;Paradkar A.;Khedekar P. | 0103-5053 | 10.5935/0103-5053.20160090 | ||||
Study on mechanism for amorphous drug stabilization using Gelucire 50/13 | 2009 | Chemical and Pharmaceutical Bulletin | 57 | 937 - 942 | Shimpi S.;Mahadik K.;Paradkar A. | 0009-2363 | 10.1248/cpb.57.937 | ||||
Apoptosis-induced anticancer effect of transferrin-conjugated solid lipid nanoparticles of curcumin | 2012 | Cancer Nanotechnology | 3 | 65 - 81 | Mulik R.;Mönkkönen J.;Juvonen R.;Mahadik K.;Paradkar A. | 1868-6958 | 10.1007/s12645-012-0031-2 | ||||
Quality by design approach: Application of artificial intelligence techniques of tablets manufactured by direct compression | 2012 | AAPS PharmSciTech | 13 | 1138 - 1146 | Aksu B.;Paradkar A.;De Matas M.;Özer O.;Güneri T.;York P. | 1530-9932 | 10.1208/s12249-012-9836-x | ||||
Study of polymorphs of progesterone by novel melt sonocrystallization technique: A technical note | 2010 | AAPS PharmSciTech | 11 | 1493 - 1498 | Tripathi R.;Biradar S.;Mishra B.;Paradkar A. | 1530-9932 | 10.1208/s12249-010-9508-7 | ||||
Combined Virtual/Experimental Multicomponent Solid Forms Screening of Sildenafil: New Salts, Cocrystals and Hybrid Salt-Cocrystals | 2018 | CRYSTAL GROWTH & DESIGN (ONLINE) | Rafael Barbas, Merce Font-Bardia, Anant Paradkar, Christopher A. Hunter, and Rafel Prohens | ACS | 10.1021/acs.cgd.8b01413 | ||||||
Mechanistic Understanding of Competitive Destabilization of Carbamazepine Cocrystals under Solvent Free Conditions | 2020 | CRYSTAL GROWTH & DESIGN (ONLINE) | https://doi.org/10.1021/acs.cgd.0c00735 | MHD Bashir Alsirawan, Xiaojun Lai, Rafel Prohens, Venu R. Vangala, Petroc Shelley, Thomas J. Bannan, David O. Topping, and Anant Paradkar | https://doi.org/10.1021/acs.cgd.0c00735 | ||||||
Interfacial Cocrystallization Using Oily Phase via Liquid−Liquid Phase Separation | 2022 | CRYSTAL GROWTH & DESIGN (ONLINE) | 22 | M. Asim Sajid Al-Hanafi, Mhd Bashir Alsirawan, Colin C. Seaton, Thomas Swift, Sudhir Pagire, Venu R. Vangala, Adrian L. Kelly, and Anant Paradkar | https://doi.org/10.1021/acs.cgd.2c00263 | ||||||
Novel nicotinamide skin-adhesive hot melt extrudates for treatment of acne | 2018 | EXPERT OPINION ON DRUG DELIVERY | 15 | Maha Nasr, Hrushikesh Karandikar, Rasha T.A. Abdel-Aziz, Noha Moftah, Anant Paradkar | 1742-5247 | Taylor and Francis | 10.1080/17425247.2018.154628 | ||||
Effect of drug content and agglomerate size on tabletability and drug release characteristics of bromhexine hydrochloridetalc agglomerates prepared by crystallo-co-agglomeration | 2010 | Acta Pharmaceutica | 60 | 25 - 38 | Jadhav N.;Pawar A.;Paradkar A. | 1330-0075 | 10.2478/v10007-010-0002-2 | ||||
Characterization of thermal and rheological properties of zidovidine, lamivudine and plasticizer blends with ethyl cellulose to assess their suitability for hot melt extrusion | 2011 | European Journal Of Pharmaceutical Sciences | 44 | 471 - 478 | Maru S.;De Matas M.;Kelly A.;Paradkar A. | 0928-0987 | 10.1016/j.ejps.2011.09.003 | ||||
Liquid crystalline phase as a probe for crystal engineering of lactose: Carrier for pulmonary drug delivery | 2015 | European Journal Of Pharmaceutical Sciences | 68 | 43 - 50 | Patil S.;Mahadik K.;Paradkar A. | 0928-0987 | 10.1016/j.ejps.2014.11.007 | ||||
Ultrasound assisted cocrystallization from solution (USSC) containing a non-congruently soluble cocrystal component pair: Caffeine/maleic acid | 2010 | European Journal Of Pharmaceutical Sciences | 41 | 597 - 602 | Aher S.;Dhumal R.;Mahadik K.;Paradkar A.;York P. | 0928-0987 | 10.1016/j.ejps.2010.08.012 | ||||
Development of curcuminoids loaded poly(butyl) cyanoacrylate nanoparticles: Physicochemical characterization and stability study | 2009 | European Journal Of Pharmaceutical Sciences | 37 | 395 - 404 | Mulik R.;Mahadik K.;Paradkar A. | 0928-0987 | 10.1016/j.ejps.2009.03.009 | ||||
Design and evaluation of celecoxib porous particles using melt sonocrystallization. | 2006 | Paradkar, Anant R.; Maheshwari, M.; Kamble, R.; Grimsey, Ian M.; York, Peter | |||||||||
ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxicity using in vitro cell culture model | 2010 | Mulik, R.S.; Monkkonen, J.; Juvonen, R.O.; Mahadik, K.R.; Paradkar, Anant R. | |||||||||
Shear and extensional rheology of hydroxypropyl cellulose melt using capillary rheometry | 2009 | Paradkar, Anant R.; Kelly, Adrian L.; Coates, Philip D.; York, Peter | |||||||||
Microstructural elucidation of self-emulsifying system: effect of chemical structure | 2012 | Patil, S.S.; Venugopal, E.; Bhat, S.; Mahadik, K.R.; Paradkar, Anant R. | |||||||||
Probing influence of mesophasic transformation on performance of self-emulsifying system: effect of ion | 2012 | Patil, S.S.; Venugopal, E.; Bhat, S.; Mahadik, K.R.; Paradkar, Anant R. | |||||||||
Monitoring ibuprofen-nicotinamide cocrystal formation during solvent free continuous cocrystallization (SFCC) using near infrared spectroscopy as a PAT tool | 2012 | Kelly, Adrian L.; Gough, Timothy D.; Dhumal, Ravindra S.; Halsey, S.A.; Paradkar, Anant R. | |||||||||
Polymorphic transformation of artemisinin by high temperature extrusion | 2013 | Kulkarni, Chaitrali S.; Kendrick, John; Kelly, Adrian L.; Gough, Timothy D.; Dash, Radha C.; Paradkar, Anant R. | |||||||||
Cocrystalization and simultaneous agglomeration using hot melt extrusion | 2010 | Dhumal, Ravindra S.; Kelly, Adrian L.; York, Peter; Coates, Philip D.; Paradkar, Anant R. | |||||||||
Stoichiometric control of co-crystal formation by solvent free continuous co-crystallization (SFCC). | 2015 | Kulkarni, Chaitrali S.; Wood, Clive; Kelly, Adrian L.; Gough, Timothy D.; Blagden, Nicholas; Paradkar, Anant R. | |||||||||
Investigation of Plasma Treatment on Micro-Injection Moulded Microneedle for Drug Delivery | 2015 | Nair, Karthik Jayan; Whiteside, Benjamin R.; Grant, Colin A.; Patel, Rajnikant; Tuinea-Bobe, Cristina-Luminita; Norris, Keith; Paradkar, Anant R. | |||||||||
Controlled release floating multiparticulates of metoprolol succinate by hot melt extrusion | 2015 | Malode, V.N.; Paradkar, Anant R.; Devarajan, P.V. | |||||||||
Development of selective DprE1 inhibitors: Design, synthesis, crystal structure and antitubercular activity of benzothiazolylpyrimidine-5-carboxamides | 2015 | Chikhale, R.; Menghani, S.; Babu, R.; Bansode, Ratnadeep V.; Bhargavi, G.; Karodia, Nazira; Rajasekharan, M.V.; Paradkar, Anant R.; Khedekar, Pramod | |||||||||
A novel transflectance near infrared spectroscopy technique for monitoring hot melt extrusion | 2015 | Kelly, Adrian L.; Halsey, S.A.; Bottom, R.A.; Korde, Sachin A.; Gough, Timothy D.; Paradkar, Anant R. | |||||||||
Coformer Replacement as an Indicator for Thermodynamic Instability of Cocrystals: Competitive Transformation of Caffeine:Dicarboxylic Acid | 2016 | Alsirawan, M.H.D. Bashir; Vangala, Venu R.; Kendrick, John; Leusen, Frank J.J.; Paradkar, Anant R. | Alsirawan MHD B, Vangala VR, Kendrick J, Leusen FJJ and Paradkar A (2016) Coformer Replacement as an Indicator for Thermodynamic Instability of Cocrystals: Competitive Transformation of Caffeine:Dicarboxylic Acid. Crystal growth & design. Online before print, May 2016. DOI http://dx.doi.org/10.1021/acs.cgd.6b00458 | ||||||||
Effect of Ultrasound on Molecular Structure Development of Polylactide | 2014 | Bao, W.; Wu, H.; Guo, S.; Paradkar, Anant R.; Kelly, Adrian L.; Brown, Elaine C.; Coates, Philip D. | |||||||||
Design, synthesis and pharmacological evaluation of pyrimidobenzothiazole-3-carboxylate derivatives as selective L-type calcium channel blockers | 2016 | Chikhale, R.; Thorat, S.; Pant, A.; Jadhav, A.; Thatipamula, K.C.; Bansode, Ratnadeep V.; Bhargavi, G.; Karodia, Nazira; Rajasekharan, M.V.; Paradkar, Anant R.; Khedekar, Pramod | |||||||||
Tracing the architecture of caffeic acid phenethyl ester cocrystals: studies on crystal structure, solubility, and bioavailability implications | 2016 | Ketkar, S.S.; Pagire, Sudhir K.; Goud, N.R.; Mahadik, K.R.; Nangia, A.; Paradkar, Anant R. | |||||||||
Systematic identification of thermal degradation products of HPMCP during hot melt extrusion process | 2015 | Karandikar, Hrushikesh M.; Ambardekar, Rohan; Kelly, Adrian L.; Gough, Timothy D.; Paradkar, Anant R. | |||||||||
Near infra red spectroscopy as a multivariate process analytical tool for predicting pharmaceutical co-crystal concentration | 2016 | Wood, Clive; Alwati, Abdolati; Halsey, S.A.; Gough, Timothy D.; Brown, Elaine C.; Kelly, Adrian L.; Paradkar, Anant R. | |||||||||
Spherical Crystallization of Carbamazepine/Saccharin Co-Crystals: Selective Agglomeration and Purification through Surface Interactions | 2013 | Pagire, Sudhir K.; Korde, Sachin A.; Whiteside, Benjamin R.; Kendrick, John; Paradkar, Anant R. | |||||||||
Mechanism for Polymorphic Transformation of Artemisinin during High Temperature Extrusion | 2013 | Kulkarni, Chaitrali S.; Kelly, Adrian L.; Kendrick, John; Gough, Timothy D.; Paradkar, Anant R. | |||||||||
Can green synthesized propolis loaded silver nanoparticulate gel enhance wound healing caused by burns? | 2015 | Patil, S.S.; Desai, N.; Mahadik, K.R.; Paradkar, Anant R. | |||||||||
Exploring Microstructural Changes in Structural Analogues of Ibuprofen-Hosted In Situ Gelling System and Its Influence on Pharmaceutical Performance | 2015 | Patil, S.S.; Venugopal, E.; Bhat, S.; Mahadik, K.R.; Paradkar, Anant R. | |||||||||
Effect of cocrystallization techniques on compressional properties of caffeine/oxalic acid 2:1 cocrystal | 2013 | Aher, Suyog; Dhumal, Ravindra S.; Mahadik, K.R.; Ketolainen, J.; Paradkar, Anant R. | |||||||||
A quality by design approach using artificial intelligence techniques to control the critical quality attributes of ramipril tablets manufactured by wet granulation | 2013 | Aksu, B.; Paradkar, Anant R.; de Matas, Marcel; Özer, Ö.; Güneri, T.; York, Peter | |||||||||
Yeast consortium isolated from Woodfordia fruticosa flowers proved to be instrumental for traditional Ayurvedic fermentation | 2013 | Bhondave, P.; Burase, R.; Takale, S.; Paradkar, Anant R.; Patil, S.; Mahadik, K.R.; Harsulkar, A. | |||||||||
Extrusion-Spheronization of Talc using Microcrystalline Cellulose as a Pellet Aid: Part I | 2014 | Jadhav, N.; Gade, M.; Salunkhe, N.; Paradkar, Anant R. | |||||||||
Alleviating exercise-induced muscular stress using neat and processed bee pollen: oxidative markers, mitochondrial enzymes, and myostatin expression in rats | 2015 | Ketkar, S.S.; Rathore, A.S.; Kandhare, A.; Lohidasan, S.; Bodhankar, S.; Paradkar, Anant R.; Mahadik, K.R. | |||||||||
Investigation of the nutraceutical potential of monofloral Indian mustard bee pollen | 2014 | Ketkar, S.S.; Rathore, A.S.; Lohidasan, S.; Rao, L.; Paradkar, Anant R.; Mahadik, K.R. | |||||||||
A comparative study of the effect of spray drying and hot-melt extrusion on the properties of amorphous solid dispersions containing felodipine | 2014 | Mahmah, O.; Tabbakh, R.; Kelly, Adrian L.; Paradkar, Anant R. | |||||||||
Mechanism of hydrogen-bonded complex formation between ibuprofen and nanocrystalline hydroxyapatite | 2017 | Ryabenkova, Yulia; Jadav, Niten B.; Conte, M.; Hippler, M.F.A.; Reeves-McLaren, N.; Coates, Philip D.; Twigg, Peter C.; Paradkar, Anant R. | |||||||||
Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug | 2017 | Kulkarni, Chaitrali S.; Kelly, Adrian L.; Gough, Timothy D.; Jadhav, V.; Singh, K.; Paradkar, Anant R. | |||||||||
Thermodynamic investigation of carbamazepine-saccharin co-crystal polymorphs | 2017 | Pagire, Sudhir K.; Jadav, Niten B.; Vangala, Venu R.; Whiteside, Benjamin R.; Paradkar, Anant R. | |||||||||
Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology | 2018 | Korde, Sachin A.; Pagire, Sudhir K.; Pan, H.; Seaton, Colin C.; Kelly, Adrian L.; Chen, Y.; Wang, Q.; Coates, Philip D.; Paradkar, Anant R. | |||||||||
In-process rheometry as a PAT tool for hot melt extrusion | 2018 | Kelly, Adrian L.; Gough, Timothy D.; Isreb, Mohammad; Dhumal, Ravindra S.; Jones, J.W.; Nicholson, S.; Dennis, A.B.; Paradkar, Anant R. | |||||||||
Development and evaluation of nanoemulsion and microsuspension formulations of curcuminoids for lung delivery with a novel approach to understanding the aerosol performance of nanoparticles | 2019 | Al Ayoub, Yuosef; Gopalan, Rajendran C.; Najafzadeh, Mojgan; Mohammad, Mohammad A.; Anderson, Diana; Paradkar, Anant R.; Assi, Khaled H. | |||||||||
Novel nicotinamide skin-adhesive hot melt extrudates for treatment of acne | 2018 | Nasr, M.; Karandikar, H.; Abdel-Aziz, R.T.A.; Moftah, N.; Paradkar, Anant R. | |||||||||
Combined virtual/experimental multicomponent solid forms screening of sildenafil: new salts, cocrystals, and hybrid salt-cocrystals | 2018 | Barbas, R.; Font-Bardia, M.; Paradkar, Anant R.; Hunter, C.A.; Prohens, R. | |||||||||
Polymorphs of Curcumin and Its Cocrystals With Cinnamic Acid | 2019 | Rathi, N.; Paradkar, Anant R.; Gaikar, V.G. | |||||||||
Gaps in Propolis Research: Challenges Posed to Commercialisation and the Need for an Holistic Approach | 2019 | Katekhaye, S.; Fearnley, H.; Fearnley, J.; Paradkar, Anant R. |